Cancer

The binding interface between a peptide and its Bcl-2 protein target is composed of common structural motifs known as TERMs.

Predicting sequence from structure

Researchers have devised a faster, more efficient way to design custom peptides and perturb protein-protein interactions.

February 15, 2019

At left, photoreceptor cells of the retina have undergone severe damage after treatment with an alkylating agent. This damage is exacerbated by the DNA repair enzyme Aag. At right, photoreceptor cells lacking Aag appear normal following treatment with the alkylating agent.

Why too much DNA repair can injure tissue

Overactive repair system promotes cell death following DNA damage by certain toxins, study shows.

February 12, 2019

MIT biological engineers have developed a way to rapidly measure cell survival rates by growing many cell colonies and imaging their fluorescently labeled DNA.

A better way to measure cell survival

New test rapidly evaluates the effect of drugs and potentially toxic compounds on cells.

February 5, 2019

MIT researchers found that lung tumors in mice treated with antibiotics (right, purple stain) were much smaller than untreated lung tumors (left).

Bacteria promote lung tumor development, study suggests

Antibiotics or anti-inflammatory drugs may help combat lung cancer.

January 31, 2019

MIT researchers’ new platform detects and extracts rare circulating tumor cells from live mouse models using a combination of laser excitation and a microfluidic chip.

From microfluidics to metastasis

New platform enables longitudinal studies of circulating tumor cells in mouse models of cancer.

January 21, 2019

MIT researchers have 3-D printed a novel microfluidic device that simulates cancer treatments on biopsied tumor tissue — and keeps the tissue alive for days — so clinicians can better examine how individual patients will respond to different therapeutics.

To guide cancer therapy, device quickly tests drugs on tumor tissue

Inexpensive 3-D-printed microfluidics device could be used to personalize cancer treatment.

December 12, 2018

MIT researchers are developing ribonucleases as potential drugs to treat cancer. In a new study, they found that the drugs work better when given with already-approved drugs known as kinase inhibitors.

New drug combination could be more effective against melanoma

Chemists discover an unexpected synergy between two types of cancer drugs.

December 3, 2018

An enzyme encircles the double helix to repair a broken strand of DNA.

The long and short of CDK12

A new study linking RNA processing to DNA repair may open new avenues to cancer therapy.

November 30, 2018

MIT engineers have designed a system that can repeatedly measure cancer cells as they flow through an array of mass sensors. Once the cells reach the end, they are collected for RNA-sequencing.

Measuring cancer cell “fitness” reveals drug susceptibility

Together, cell growth rate and gene expression shed light on why some tumor cells survive treatment.

November 29, 2018

Kerrie Greene’s work in the Saxe lab explores an area with many unknowns: infant and early childhood cognition, learning, and brain development.

Exploring unknowns in cancer, the human brain, and the road ahead

Double major Kerrie Greene builds connections in her research and her community.

November 18, 2018

MIT engineers grew these mesenchymal stem cells (red, with blue nuclei) on a surface with mechanical properties similar to those of bone marrow.

Helping blood cells regenerate after radiation therapy

Method boosts differentiation of stem cells into mature blood cell types, may help leukemia and lymphoma patients.

October 24, 2018

Angelika Amon wins 2019 Breakthrough Prize in Life Sciences

Four other MIT researchers to receive New Horizons Prizes in math and physics; two alumni win Breakthrough Prize in Fundamental Physics.

October 17, 2018

MIT and MGH researchers have developed an automated deep-learning model, currently being used on real patients, that identifies dense breast tissue — a risk factor for breast cancer — in mammograms as reliably as expert radiologists.

Automated system identifies dense tissue, a risk factor for breast cancer, in mammograms

Deep-learning model has been used successfully on patients, may lead to more consistent screening procedures.

October 16, 2018

MIT biological engineers have devised a way to regulate the expression of RNA once it gets into cells, giving them precise control over the dose of protein that a patient receives, as shown in this conceptual image.

This RNA-based technique could make gene therapy more effective

Biological engineers design RNA circuits that enable precise control over the dose of therapeutic protein a patient receives.

October 16, 2018

In this image of a growing mouse tumor, yellow fluorescence marks the presence of Lgr5+ cancer stem cells. Although Lgr5+ cells are only a minority of tumor cells, they are the source of all other tumor cells.

In pursuit of the elusive stem cell

New MIT initiative delves into the biology of stem cells and cancer stem cells, seeks ways to identify, purify, and propagate them.

October 15, 2018

MIT News | Massachusetts Institute of Technology

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