Cancer

Tyler Jacks (left), head of the Lustgarten Laboratory for Pancreatic Cancer Research at MIT, and Kerri Kaplan, president and chief executive officer of the Lustgarten Foundation, both say they are excited to usher in a new era of pancreatic cancer research.

Progress against pancreatic cancer

Lustgarten Foundation names MIT laboratory to improve understanding and treatment of a deadly disease

October 11, 2018

It's often unclear how to turn molecular knowledge into new therapeutics, especially for cancers with no clear genetic cause like medulloblastoma.

Protein analysis uncovers new medulloblastoma subtypes

Research team shows the power of proteomics to discover new drug targets and help develop therapeutic strategies with fewer long-term side effects.

September 14, 2018

Exploring cancer metabolism

Matthew Vander Heiden seeks new cancer treatments that exploit tumor cells’ abnormal metabolism.

August 28, 2018

The new system was developed by a CSAIL group led by Professor Dina Katabi (pictured)

A "GPS for inside your body"

CSAIL wireless system suggests future where doctors could implant sensors to track tumors or even dispense drugs.

August 20, 2018

MIT researchers aim to improve the quality of life for patients suffering from glioblastoma, the most aggressive form of brain cancer, with a machine-learning model that makes chemotherapy and radiotherapy dosing regimens less toxic but still as effective as human-designed regimens.

Artificial intelligence model “learns” from patient data to make cancer treatment less toxic

Machine-learning system determines the fewest, smallest doses that could still shrink brain tumors.

August 9, 2018

Sensor could help doctors select effective cancer therapy

Hydrogen peroxide-sensing molecule reveals whether chemotherapy drugs are having their intended effects.

August 7, 2018

A team of researchers hopes to extend patients’ lifespan by delivering directly to the brain a drug that targets a mutation found in 20 to 25 percent of all gliomas.

A targeted approach to treating glioma

With new method, surgeons would remove tumor, then implant microparticles that attack remaining cancer cells.

August 6, 2018

Findings from the Whitehead Institute at MIT not only help illuminate the biology of a well-known cancer chemotherapy, but also suggest a simple dietary supplement that could help broaden its therapeutic window and reduce its toxicity.

Scientists sharpen the edges of cancer chemotherapy

Whitehead team deploys CRISPR tools to better understand and uncover ways of improving methotrexate, a popular chemotherapy drug.

July 12, 2018

MIT engineers have designed nanoparticles that can be attached to T cells and release T-cell-stimulating molecules called cytokines (yellow spheres). These cytokines activate T cells (blue) to attack nearby tumor cells.

Nanoparticles give immune cells a boost

Drugs carried in cellular “backpacks” help T cells to destroy tumors.

July 9, 2018

This osteosarcoma cell appears with DNA in blue, mitochondria in yellow, and actin filaments in purple.

Restricting a key cellular nutrient could slow tumor growth

Researchers identify the amino acid aspartate as a metabolic limitation in certain cancers.

June 28, 2018

Great progress has been made in reducing the cancer death toll through better prevention and screening, according to a new article by MIT Professor Emerita Nancy Hopkins and colleagues.

3Q: Nancy Hopkins on the impact and potential of cancer prevention

Mechanism-based cancer prevention is poised to further decrease the numbers of U.S. cancer deaths, says MIT professor emerita.

June 25, 2018

This image shows pancreatic cancer cells (nuclei in blue) growing as a sphere encased in membranes (red).

Biologists discover how pancreatic tumors lead to weight loss

Shortfall of digestive enzymes can lead to tissue breakdown in early stages of pancreatic cancer.

June 20, 2018

MIT researchers have designed brain-tumor-targeting nanoparticles that can carry two different drugs, one in the core and one in the outer shell.

Tiny particles could help fight brain cancer

Nanoparticles carrying two drugs can cross the blood-brain barrier and shrink glioblastoma tumors.

May 24, 2018

Intestinal stem cells from mice that fasted for 24 hours, at right, produced much more substantial intestinal organoids than stem cells from mice that did not fast, at left.

Fasting boosts stem cells’ regenerative capacity

A drug treatment that mimics fasting can also provide the same benefit, study finds.

May 3, 2018

Perioperative NSAIDs may prevent early metastatic relapse in post-surgical breast cancer patients

Mouse study links early metastasis to systemic inflammation caused by wound healing.

April 11, 2018

MIT News | Massachusetts Institute of Technology

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