Measuring cancer cell state can reveal drug susceptibility
Study results also show that pancreatic tumor cells can be forced into a more susceptible state by changing their environment.
Engineers devise a way to selectively turn on RNA therapies in human cells
A new RNA-based control switch could be used to trigger production of therapeutic proteins to treat cancer or other diseases.
RNA-targeting enzyme expands the CRISPR toolkit
Exploring diversity among bacterial immune systems, McGovern Institute scientists uncovere a programmable system for precisely targeting and modifying RNA.
New programmable gene editing proteins found outside of CRISPR systems
Researchers find RNA-guided enzymes are more diverse and widespread than previously believed.
Scientists harness human protein to deliver molecular medicines to cells
Made of components found in the human body, the programmable system is a step toward safer, targeted delivery of gene editing and other molecular therapeutics.
SMART researchers develop a method for rapid, accurate virus detection
Four times faster than conventional PCR methods, new RADICA approach is highly specific, sensitive, and resistant to inhibitors.
An on-off switch for gene editing
New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.
Basic cell health systems wear down in Huntington’s disease, analysis shows
A new computational approach for analyzing complex datasets shows that as disease progresses, neurons and astrocytes lose the ability to maintain homeostasis.
A high-resolution glimpse of gene expression in cells
Expanding tissue samples before sequencing allows researchers to pinpoint locations of RNA molecules.
Scientists seek insight into Parkinson’s, addiction by tracking gene expression in the brain
Two MIT faculty members earn funding from the G. Harold and Leila Y. Mathers Foundation.
RNA molecules are masters of their own destiny
Research suggests the products of transcription — RNA molecules — regulate their own production through a feedback loop.
3 Questions: Phillip Sharp on the discoveries that enabled mRNA vaccines for Covid-19
Curiosity-driven basic science in the 1970s laid the groundwork for today’s leading vaccines against the novel coronavirus.
Explained: Why RNA vaccines for Covid-19 raced to the front of the pack
Many years of research have enabled scientists to quickly synthesize RNA vaccines and deliver them inside cells.
Regulating the regulators
Tiny microRNAs help destroy unwanted messenger RNAs in cells. New research finds how the body keeps them in check.
Silencing gene expression to cure complex diseases
Immuneering uses bioinformatics to develop new medicines while also helping large pharmaceutical companies improve their treatments.