Researchers map brain cell changes in Alzheimer’s disease
Study reveals key cell structures and gene expression changes near amyloid plaques and tau tangles in mouse brain tissue.
Paying it forward
When she’s not analyzing data about her favorite biomolecule, senior Sherry Nyeo focuses on improving the undergraduate experience at MIT.
How Huntington’s disease affects different neurons
A new study identifies cells that are the most vulnerable within a brain structure involved in mood and movement.
New technologies reveal cross-cutting breakdowns in Alzheimer’s disease
“Single-cell profiling” is helping neuroscientists see how disease affects major brain cell types and identify common, potentially targetable pathways.
New CRISPR-based tool inserts large DNA sequences at desired sites in cells
Known as PASTE, the technique holds potential for treating a variety of diseases caused by faulty genes.
When cells’ tiny differences have far-reaching implications
Alex Shalek’s technologies for single-cell RNA profiling can help dissect the cellular bases of complex diseases around the globe.
Robert Langer wins BBVA Foundation Frontiers of Knowledge Award
Institute Professor honored for groundbreaking work in nucleic acid delivery and nanoparticles.
New CRISPR-based map ties every human gene to its function
Jonathan Weissman and collaborators used their single-cell sequencing tool Perturb-seq on every expressed gene in the human genome, linking each to its job in the cell.
Convenience-sized RNA editing
MIT neuroscientists expand CRISPR toolkit with new, compact Cas7-11 enzyme.
3 Questions: Daniel Anderson on the progress of mRNA vaccines
Following the successful development of vaccines against Covid-19, scientists hope to deploy mRNA-based therapies to combat many other diseases.
Aging Brain Initiative awards fund five new ideas to study, fight neurodegeneration
Competitive seed grants launch yearlong investigations of novel hypotheses about potential causes, biomarkers, treatments of Alzheimer’s and ALS.
Advocating for vaccine equity
Postdoc Digbijay Mahat became a cancer researcher to improve health care in Nepal, but the Covid-19 pandemic exposed additional resource disparities.
New computational tool predicts cell fates and genetic perturbations
The technique can help predict a cell’s path over time, such as what type of cell it will become.
Making RNA vaccines easier to swallow
A pill that releases RNA in the stomach could offer a new way to administer vaccines, or to deliver therapies for gastrointestinal disease.
Speeding up directed evolution of molecules in the lab
Using a new robotic platform, researchers can simultaneously track hundreds of microbial populations as they evolve new proteins or other molecules.