Picower Institute for Learning and Memory

MIT neuroscientists have performed a comprehensive study of the APOE4 gene, which increases risk for Alzheimer’s disease, and the more common form of the gene, APOE3.

Neuroscientists discover roles of gene linked to Alzheimer’s

Study reveals why people with the APOE4 gene have higher risk of the disease.

May 31, 2018

It’s often said that experience is the best teacher, but the experiences of other people may be even better.

Brain circuit helps us learn by watching others

Scientists pinpoint neural interactions that are necessary for observational learning.

May 3, 2018

Three brain regions collaborate to produce working memory, but when it reaches capacity, their synchrony breaks down.

A heavy working memory load may sink brainwave 'synch'

Picower Institute study explains what happens when working memory reaches its full capacity.

April 6, 2018

School of Science announces Infinite Mile Awards for 2018

Seven staff members honored for their outstanding contributions to the MIT community.

April 3, 2018

The MVP protein appears green in these stained neurons (red denotes neuronal marker SATB2).

Researchers identify important role for gene in 16p11.2 deletion autism

Study finds that major vault protein is needed for homeostatic plasticity.

March 21, 2018

As both a neuroscientist and an anesthesiologist, Emery Brown wants to make the brain the center of field.

Putting the brain at the center of anesthesiology

Emery N. Brown explains how statistics and neuroscience improve anesthesiology at the American Association for the Advancement of Science's annual meeting.

February 16, 2018

In this image of a mouse visual cortex, astrocytes (stained red) appear about as abundant as neurons (green).

MIT neuroscientists give "invisible" cells a new look

With a new grant, a Picower Institute team is studying the role of astrocytes, which may partner with neurons to process information in the brain.

February 12, 2018

MIT neuroscientists have found evidence that the brain’s ability to control what it’s thinking about relies on low-frequency brain waves known as beta rhythms.

New study reveals how brain waves control working memory

Brain rhythms act as a gate for information entering and leaving the mind.

January 26, 2018

Sometimes items can easily be grouped by their appearance, such as these apples, but sometimes the brain must use a different mode of thought to find a more abstract similarity, such as that between a drill and screwdriver.

Study: Distinct brain rhythms and regions help us reason about categories

High-frequency gamma oscillations sort similar-looking objects; lower-frequency beta oscillations kick in when connections are more abstract.

January 25, 2018

Various 3-D views of the basolateral amygdala show the arrangement of neurons that project to the nucleus accumbens (green), the hippocampus (blue), or the central amygdala (red).

Lifting the veil on "valence," brain study reveals roots of desire and dislike

Researchers map the amygdala's distinct but diverse and dynamic neighborhoods where feelings are assigned.

January 23, 2018

School of Science Infinite Kilometer Awards for 2017

Eight research staffers and postdocs are recognized for their extraordinary contributions and dedication to programs, colleagues, and the Institute.

January 16, 2018

Study: Rhythmic interactions between cortical layers underlie working memory

MIT neuroscientists suggest a model for how we gain volitional control of what we hold in our minds.

January 15, 2018

The image shows the locus coeruleus, which drives neuronal circuits of the hippocampus and enables novel contextual memory. The red staining shows norepinephrine transporter (NET)-positive cells, indicating the locus coeruleus. The green staining shows adeno-associated virus (AAV)-mediated expressions of light-sensitive inhibitory opsin, archaerhodopsin (Arch). The blue staining shows all cells in...

How the brain selectively remembers new places

Neuroscientists identify a circuit that helps the brain record memories of new locations.

December 25, 2017

Using a novel analytical method they have developed, MIT researchers analyzed raw brain activity data (B). The spectrogram shows decreased noise and increased frequency resolution, or contrast (E and F) compared to standard spectral analysis methods (C and D).

Recalculating time

A novel algorithm enables statistical analysis of time series data.

December 21, 2017

In searching for a potential therapeutic for autism spectrum disorder, researchers have found that R-Baclofen reverses cognitive deficits and improves social interactions in two lines of 16p11.2 deletion mice.

Promise seen in possible treatment for autism spectrum disorder

Studies in mice show improved social interaction and cognition from a potential therapeutic for a syndrome that often results in autism.

October 31, 2017

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