Whitehead Institute

Prof. Emerita Mary-Lou Pardue, a cellular and molecular biologist whose work “formed the foundation for key advancements and discoveries in understanding the structure of chromosomes,” has died at age 90, reports Bryan Marquard for The Boston Globe. Pardue “was a role model of what women in science can be at a time when there weren’t a lot of those, and a trailblazer as a woman,” emphasizes Ky Lowenhaupt, manager of the Biophysical Instrumentation Facility at MIT, “but also a trailblazer as a scientist who didn’t do things along the path that other people took.”

Sonia Vallabh and Eric Minikel, senior group leaders from the Broad Institute have created a gene-editing tool to combat prion diseases, reports Karen Weintraub for USA Today. The approach “should also work against diseases such as Huntington's, Parkinson's, ALS and even Alzheimer's, which result from the accumulation of toxic proteins,” Weintraub writes.

Prof. Jonathan Weissman and his colleagues have developed a new tool for monitoring changes in human blood cells, which could one day help researchers predict disease risk, reports Megan Molteni for STAT. “The technology paves the way for a day in the not too distant future where it is conceivable that from a simple blood draw, a doctor could get a sense of what’s going on in that patient’s bone marrow,” writes Molteni, “picking up perturbations there that could help predict a diverse range of diseases.”

Prof. Richard Young and his colleagues have discovered that many transcription factors can bind RNA, reports Christie Wilcox for Science. "The team decided to investigate after scattered reports suggested that at least some transcription factors are capable of binding RNA even though they lack traditional RNA binding domains,” writes Wilcox. 

CAMP4, a startup founded by Prof. Richard Young, is developing a new class of RNA-based therapies to treat genetic diseases, reports Ryan Cross for The Boston Globe. The “startup’s experimental approach will allow it to dial up the output of genes to treat genetic diseases, with an initial focus on a severe form of epilepsy and life-threatening live diseases,” writes Cross.

UPI reporter Brooks Hays writes that a new tool developed by researchers from MIT and other institutions can precisely control gene expression without altering the underlying gene sequence. “Scientists hope this new ability to silence any part of the human genome will lead to powerful insights into functionality of the human genome, as well as inspire new therapies for a variety of diseases and genetic disorders,” writes Hays.

Prof. Ruth Lehmann, director of the Whitehead Institute, speaks with STAT reporter Elizabeth Cooney about the importance of fundamental scientific research. “There are so many areas that are so important for science,” says Lehmann. “One is supporting fundamental research. But then there are other areas like diversity and disparities.”

CBS News reporter Sophie Lewis spotlights NASA astronauts Jasmin Moghbeli '05 and Kate Rubins, a former researcher at MIT’s Whitehead Institute, noting that they are training for the upcoming Artemis missions, which will "send the first woman to walk on the moon."

Professor Angelika Amon, an award-winning cell biologist and “an advocate for the kinds of studies that grind away outside of the limelight,” died on Oct. 29, reports Bryan Marquard for The Boston Globe. Amon’s daughter, Clara Weis, noted that Amon “was pretty much the best role model there is. She was very caring and understanding. She always knew what was happening and how to deal with it the right way.”

Times Higher Ed reporter Matthew Reisz memorializes the life and work of Prof. Angelika Amon, a “trailblazing” scientist known for her research into the life cycle of cells. “Angelika existed in a league of her own,” says Whitehead fellow Kristin Knouse. “She had the energy and excitement of someone who picked up a pipette for the first time, but the brilliance and wisdom of someone who had been doing it for decades.”

Writing for The Washington Post, Prof. Harvey Lodish emphasizes the importance of foreign workers and immigrants to the U.S. economy. “Without students and workers from outside the U.S., it’s difficult to see how the current successes of U.S. scientific research and innovation could continue,” writes Lodish.

A new study by MIT researchers explores how cellular guides in planarians appear to provide a roadmap for regeneration, reports Veronique Greenwood for The New York Times. Greenwood notes that the findings “may someday help scientists interested in helping humans regenerate injured neurons.”

MIT researchers have developed a new technique to synthesize the feel-good molecules in the Kava plant root, reports Carey Goldberg for WBUR. “What we do in our lab is to actually start from plants that have thousands of years of use in traditional medicine," says Prof. Jing-Ke Weng. "We already know there's something in that plant that works to treat some illness."

A new study by MIT researchers finds that there are differences in how genes are used in men and women, reports Angus Chen for WBUR. “I think we are at present missing a lot because we operate with what is essentially a unisex model in biomedical research,” explains Prof. David Page.

Writing for STAT, Eric Boodman highlights how Prof. Jing-Ke Weng’s lab at the Whitehead Institute has mapped the genome of a firefly in an effort to understand how fireflies acquired the ability to glow. The researchers hope their findings will eventually be used to develop “better laboratory tools for studying disease and developing treatments.”