MIT scientists have developed a technique that could potentially be used one day to treat diseases of the brain, muscles, liver and kidneys by using CRISPR to edit RNA, writes Melissa Healy for The Los Angeles Times. Making edits to the chemical message of RNA, “doesn’t effect a permanent change in a cell’s architectural plan; rather, it essentially alters the implementation of that plan,” explains Healy.
Prof. Feng Zhang and his colleagues have created a CRISPR-based system that can edit RNA in human cells, reports Amy Dockser Marcus for The Wall Street Journal. “The new RNA-editing system, which the scientists have dubbed Repair, allows the editing of individual RNA letters, correcting a common mutation known to play a role in a number of diseases.”
Financial Times reporter Clive Cookson writes that Prof. Feng Zhang and his colleagues have engineered CRISPR so that it can edit single RNA letters in human cells. Cookson explains that the researchers believe that, “RNA editing offers a safer and more flexible way to make corrections than the permanent changes involved in DNA editing.”
TIME reporter Alice Park writes that MIT researchers have modified the CRISPR gene-editing system so that it could be used to diagnose disease. Park explains that the researchers, “used CRISPR to recognize specific substances that bacteria and viruses make. Picking up even the slightest whisper of these products can alert doctors that an infection is active.”
MIT researchers have developed a new technique that uses the CRISPR gene-editing system to diagnose diseases, reports Joel Achenbach for The Washington Post. Achenbach explains that the tool could potentially be used to “detect not only viral and bacterial diseases but also potentially for finding cancer-causing mutations.”
Straits Times reporter Nadia Chevroulet writes that researchers from MIT and the Singapore-MIT Alliance for Research and Technology (SMART) have uncovered how certain bacteria evade the body’s defenses. The findings could provide “new ways to counter tuberculosis, and possibly a new generation of drugs to battle antibiotic resistance.”
MIT researchers have developed a programmable vaccine that could be used to respond to disease outbreaks, reports Ben Gruber for Reuters. The vaccine harnesses “messenger RNA, a genetic material that can be programmed to fight any viral, bacterial or parasitic disease by provoking an amplified immune response.”
MIT researchers have discovered that a bacterium found in the human mouth can be used to form a new CRISPR gene-editing system that can target RNA, reports Carl Zimmer for The New York Times. The development “may open up a new front in gene engineering, gaining the ability to precisely adjust the proteins in cells, for instance, or to target cancer cells."
New Scientist reporter Colin Barras writes that MIT researchers have found they can program C2c2, an enzyme found in bacteria, to serve as an RNA-editing tool. Barras writes that the tool “promises to transform our understanding of RNA’s role in our growth and development, and provide a new avenue for treating infectious diseases and cancer.”