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AFP

Researchers at MIT have developed a mobile printer that could create microneedle patches for mRNA vaccine delivery. “These "microneedle patches" offer a range of advantages over traditional jabs in the arm, including that they can be self-administered, are relatively painless, could be more palatable to the vaccine-hesitant and can be stored at room temperature for long periods of time,” writes Daniel Lawler for Agence France-Presse.

Genetic Engineering & Biotechnology News

Research scientist Ana Jaklenec spoke with Jonathan Grinstein at Genetic Engineering & Biotechnology News about a new microneedle patch printer she and her colleagues have developed that may one day enable on-demand vaccine manufacturing. “The idea was that you could, in an emergency situation, deploy some of these printers and locally vaccinate the population to prevent the global spread of infection,” says Jaklenec.

The Boston Globe

Jake Becraft PhD ’19 and former postdoctoral associate Tasuku Kitada co-founded Strand Therapeutics, a biotech firm developing mRNA therapies for cancer, reports Ryan Cross for The Boston Globe. They created “a way to activate mRNA in the presence of particular microRNAs – a much more useful application for therapies,” writes Cross. 

The Boston Globe

Researchers at MIT have developed new gene-editing technology that can move large sequences of DNA into the human genome, reports Ryan Cross for The Boston Globe. “The molecular tool gives scientists a new way to completely replace broken genes, paving the way to potential cures for diseases such as cystic fibrosis,” writes Cross.

The Boston Globe

Scientists from MIT, Duke and Stanford have developed a new technique to make gene therapies safer and more effective, reports Ryan Cross for The Boston Globe. “It’s about making these therapies much smarter and programmable,” says Jonathan S. Gootenberg, a research scientist at the McGovern Institute.

The Boston Globe

CAMP4, a startup founded by Prof. Richard Young, is developing a new class of RNA-based therapies to treat genetic diseases, reports Ryan Cross for The Boston Globe. The “startup’s experimental approach will allow it to dial up the output of genes to treat genetic diseases, with an initial focus on a severe form of epilepsy and life-threatening live diseases,” writes Cross.

Bloomberg Businessweek

Orna Therapeutics, which was co-founded by MIT researchers, is working on “programming RNA with genetic code that instructs a line to split into several strands and then repair itself in the shape of a circle,” reports Bloomberg Businessweek reporter Angelica LaVito. “Delivering those messages via circles may produce a more stable, longer-lasting signal, potentially treating cancer, autoimmune disorders, and genetic diseases.”

The Boston Globe

Boston Globe columnist Shirley Leung spotlights how the development of the Moderna Covid-19 vaccine demonstrates the success of the Massachusetts life sciences sector. “For more than half a century, the Massachusetts Institute of Technology has been the epicenter of that curiosity, with a focus on molecular biology — initially to find a cure for cancer,” writes Leung. “There have been Nobel laureates collaborating on cancer, genetics, and immunology, along with future laureates making discoveries in how RNA, a molecule that is as fundamental as DNA to cell function, can be used in medicine.”

WBUR

Reporting for WBUR, Carey Goldberg highlights how MIT researchers have developed a new RNA editing tool that could be used to tweak a gene that raises the risk of Alzheimer’s disease. As the effects of RNA editing are not permanent, “it's almost like a small, pill-like version of gene therapy,” explains research scientist and McGovern Fellow Omar Abudayyeh.

Boston Globe

A new study by MIT researchers provides evidence that life on Earth may have begun in shallow bodies of water, reports Martin Finucane for The Boston Globe. The researchers found that ponds “could have held high concentrations of a key ingredient, nitrogen, while that would have been less likely in the ocean,” Finucane explains.

Xinhuanet

A new study by MIT researchers provides evidence that the first life on Earth likely came from shallow ponds, not oceans, reports the Xinhua news agency. The researchers found that primitive ponds that were about “10 centimeters deep had higher concentrations of nitrogen, a key ingredient for life on Earth.”

Scientific American

MIT researchers have developed an inhalable form of messenger RNA that could be used to help treat patients with lung disease, reports Christopher Intagliata for Scientific American. Intagliata explains that researchers hope to one day “use this technique to help cystic fibrosis patients.”

Gizmodo

Researchers at the Broad Institute of MIT and Harvard have programmed CRISPR to “in essence, make edits when significant cellular events occur,” writes Kristin Brown for Gizmodo. “All this adds up to the potential of CRISPR as not just a gene-editing powerhouse, but a multifunctional tool that also works as a biosensor, a medical detective, and an invaluable instrument for basic research.”

STAT

Originally created by the Zhang Lab in 2017, CRISPR tool SHERLOCK has been improved upon to be three times more sensitive for detecting viruses and infections using an inexpensive test strip. Sharon Begley writes for STAT News, “A paper strip, like in a pregnancy test, is dipped into a sample, and if a line appears, the target molecule was detected — no instruments required.”

The Verge

A gene-editing tool called SHERLOCK, developed in Prof. Feng Zhang’s lab, allows for faster detection of infections and viruses, such as Zika and Dengue fever. “It does this by combining different types of CRISPR enzymes, which are unleashed together to target distinct bits of DNA and RNA, another of the major biological molecules found in all forms of life,” writes Alessandra Potenza for The Verge