Cellular traffic congestion in chronic diseases suggests new therapeutic targets
Chronic diseases like diabetes are prevalent, costly, and challenging to treat. A common denominator driving them may be a promising new therapeutic target.
Creating the crossroads
Through academia and industry, Gevorg Grigoryan PhD ’07 says there is no right path — just the path that works for you.
CHARMed collaboration creates a potent therapy candidate for fatal prion diseases
A new gene-silencing tool shows promise as a future therapy against prion diseases and paves the way for new approaches to treating disease.
Protein study could help researchers develop new antibiotics
Researchers created a water-soluble version of an important bacterial enzyme, which can now be used in drug screens to identify new antibiotics.
“Rosetta Stone” of cell signaling could expedite precision cancer medicine
An atlas of human protein kinases enables scientists to map cell signaling pathways with unprecedented speed and detail.
A new computational technique could make it easier to engineer useful proteins
MIT researchers plan to search for proteins that could be used to measure electrical activity in the brain.
Exploring the cellular neighborhood
Software allows scientists to model shapeshifting proteins in native cellular environments.
How sensory gamma rhythm stimulation clears amyloid in Alzheimer’s mice
Study finds stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of an Alzheimer’s protein.
Future science at the molecular level
Brad Pentelute and his lab compel the anthrax delivery system to deliver antibody and peptide variants into cells to treat cancer.
Study explains how part of the nucleolus evolved
A single protein can self-assemble to build the scaffold for a biomolecular condensate that makes up a key nucleolar compartment.
New sensor mimics cell membrane functions
The device detects the same molecules that cell receptors do, and may enable routine early screening for cancers and other diseases.
Probe expands understanding of oral cavity homeostasis
A new approach opens the door to a greater understanding of protein-microbe interactions.
It takes three to tango: transcription factors bind DNA, protein, and RNA
Whitehead Institute researchers find many transcription factors bind RNA, which fine-tunes their regulation of gene expression, suggesting new therapeutic opportunities.
Scientists pinpoint where thousands of individual proteins are made in intact tissue and single cells
A new technology called RIBOmap can give researchers valuable insight into how protein production in animal and human tissue is altered in disease.
Generative AI imagines new protein structures
“FrameDiff” is a computational tool that uses generative AI to craft new protein structures, with the aim of accelerating drug development and improving gene therapy.