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The cryo-EM-generated GATOR1 structure can provide insights into its function.

Structure of key growth regulator revealed

Researchers identify the molecular structure of the GATOR1 protein complex, which regulates growth signals in human cells, using cryo-electron microscopy.

March 28, 2018

An MIT-led research team reversed age-related endurance loss in mice by treating them with a compound that promotes new blood vessel growth.

Study suggests method for boosting growth of blood vessels and muscle

Activating proteins linked to longevity may help to increase endurance and combat frailty in the elderly.

March 22, 2018

Fluorescently-tagged IAPP oligomers can be seen trafficking through yeast cells.

Toxic proteins and type 2 diabetes

Whitehead Institute study in yeast illuminates the role of a molecular de-clogger in disease biology.

March 8, 2018

Rheumatoid arthritis, which afflicts more than 1 million Americans, is an autoimmune disorder that produces swollen and painful joints, primarily affecting the wrists and hands.

New study solves an arthritis drug mystery

MIT biological engineers discover why a promising drug failed in clinical trials.

March 6, 2018

Researchers at MIT and the Allen Institute for Brain Science have developed a new modified version of the rabies virus that stops replicating once it infects a cell, allowing it to deliver its genetic cargo without harming the cell.

Viral tool traces long-term neuron activity

New technique is nontoxic to cells, should allow scientists to study neuron function for months or years instead of weeks.

March 5, 2018

Researchers hope that their work will lead to a new approach to designing and evaluating polymer stents and other types of degradable medical devices.

Study reveals why polymer stents failed

Microscopic flaws in material structure can lead to stent deformation after implantation.

February 26, 2018

MIT researchers have developed a light-sensitive protein that can be embedded into neuron membranes, where it emits a fluorescent signal that indicates how much voltage a particular cell is experiencing. This could allow scientists to study how neurons behave, millisecond by millisecond, as the brain performs a particular function.

Seeing the brain's electrical activity

Fluorescent sensor allows imaging of neurons' electrical communications, without electrodes.

February 26, 2018

Using a state-of-the-art type of electron microscopy, an MIT-led team has discovered the structure of an enzyme that is crucial for maintaining an adequate supply of DNA building blocks in human cells.

Scientists deliver high-resolution glimpse of enzyme structure

New finding suggests differences in how humans and bacteria control production of DNA’s building blocks.

February 20, 2018

New Whitehead Institute research may prove to be a useful paradigm for targeting diseases caused by abnormal methylation.

Study: Fragile X syndrome neurons can be restored

Whitehead Institute researchers are using a modified CRISPR/Cas9-guided activation strategy to investigate the most frequent cause of intellectual disability in males.

February 15, 2018

MIT cognitive scientists have found that conversation between an adult and a child appears to change the child’s brain.

Back-and-forth exchanges boost children’s brain response to language

Study finds engaging young children in conversation is more important for brain development than “dumping words” on them.

February 13, 2018

In this image of a mouse visual cortex, astrocytes (stained red) appear about as abundant as neurons (green).

MIT neuroscientists give "invisible" cells a new look

With a new grant, a Picower Institute team is studying the role of astrocytes, which may partner with neurons to process information in the brain.

February 12, 2018

This image shows neurons in the CA3 region of the hippocampus, which is important for memory encoding and retrieval. Nuclei of the CA3 neurons are labeled in green and their dendrites in red, and the smaller specks of green above represent axons projecting to the CA3 neurons from the dentate gyrus.

Study reveals molecular mechanisms of memory formation

Neuroscientists discover a cellular pathway that encodes memories by strengthening specific synapses.

February 8, 2018

Our daily lives include hundreds of routine habits, made up of many smaller actions, such as picking up our toothbrush, squeezing toothpaste onto it, and then lifting the brush to our mouth. This process of grouping behaviors together into a single routine is known as “chunking.” MIT neuroscientists have now found that certain neurons in the brain are responsible for marking the beginning and ...

Distinctive brain pattern helps habits form

Study identifies neurons that fire at the beginning and end of a behavior as it becomes a habit.

February 8, 2018

Dagdeviren (center) developed the device while working as a postdoc in the labs of Graybiel (left), Cima (right), and Langer (far left).

Ultrathin needle can deliver drugs directly to the brain

Miniaturized system could be used to treat neurological disorders that affect specific brain regions.

January 24, 2018

MIT biologists have designed a new peptide that can disrupt a key protein that many types of cancers, including some forms of lymphoma, leukemia, and breast cancer, need to survive.

Biologists’ new peptide could fight many cancers

Drug that targets a key cancer protein could combat leukemia and other types of cancer.

January 15, 2018