MIT scientists have developed a technique that could potentially be used one day to treat diseases of the brain, muscles, liver and kidneys by using CRISPR to edit RNA, writes Melissa Healy for The Los Angeles Times. Making edits to the chemical message of RNA, “doesn’t effect a permanent change in a cell’s architectural plan; rather, it essentially alters the implementation of that plan,” explains Healy.
Prof. Feng Zhang and his colleagues have created a CRISPR-based system that can edit RNA in human cells, reports Amy Dockser Marcus for The Wall Street Journal. “The new RNA-editing system, which the scientists have dubbed Repair, allows the editing of individual RNA letters, correcting a common mutation known to play a role in a number of diseases.”
Financial Times reporter Clive Cookson writes that Prof. Feng Zhang and his colleagues have engineered CRISPR so that it can edit single RNA letters in human cells. Cookson explains that the researchers believe that, “RNA editing offers a safer and more flexible way to make corrections than the permanent changes involved in DNA editing.”
Prof. Feng Zhang has been awarded the Lemelson-MIT Prize, reports Sharon Begley for STAT. Zhang was honored for his, “track record of innovations and of coming up with big ideas that change fields,” explains Prof. Michael Cima, faculty director of the award. “Zhang is one of those individuals who move through groups of talented people sparking new ideas.”
NBC News reporter Maggie Fox writes that MIT researchers have developed a noninvasive brain stimulation technique that could eventually offer relief to patients with diseases like Parkinson’s and epilepsy without requiring surgery. Fox explains that the method allows for sending, “electrical signals deep into the brain without affecting the layers in between.”
MIT researchers have developed a noninvasive method to stimulate specific neurons deep in the brain that could be used to help treat patients with diseases such as Parkinson’s, reports Meredith Wadman for Science. This new method could also allow scientists to “selectively prod deep-brain neurons into action,” explains Wadman.
Writing for Wired, Abigail Beal highlights how MIT researchers have developed a noninvasive technique to trigger reactions in deep brain cells using low frequency electrical signals. “If we could noninvasively stimulate deep regions, without hitting overlying regions, we might be able to help more people because we could stimulate deep regions selectively, without needing surgery,” explains Prof. Ed Boyden.
MIT researchers have developed a non-invasive technique for deep brain stimulation, which could be used to help patients with brain diseases, reports Mo Costandi for The Guardian. “Targets for disorders such as depression, Alzheimer’s, PTSD, and so forth, are deep in the brain, and they might be more selectively stimulatable with our method,” says Prof. Ed Boyden.
Meg Tirrell of CNBC spotlights research by Prof. Li-Huei Tsai that shows that flashing lights could be used as a non-invasive treatment method for Alzheimer’s disease. Tsai and her colleagues found that flashing light could potentially be used to restore gamma rhythms in the brain, which are often impaired in people with Alzheimer’s.
Inside Higher Ed reporter Colleen Flaherty writes that researchers from MIT and around the world are publicly defending the late Prof. Suzanne Corkin’s work with patient H.M. in response to a highly critical publication. When “so many scholars rise to defend the reputation of a deceased colleague,” says Arthur Caplan, head of NYU’s Division of Bioethics, “that speaks volumes both about her and the problems that exist in the book.”
MIT researchers have discovered that a bacterium found in the human mouth can be used to form a new CRISPR gene-editing system that can target RNA, reports Carl Zimmer for The New York Times. The development “may open up a new front in gene engineering, gaining the ability to precisely adjust the proteins in cells, for instance, or to target cancer cells."
New Scientist reporter Colin Barras writes that MIT researchers have found they can program C2c2, an enzyme found in bacteria, to serve as an RNA-editing tool. Barras writes that the tool “promises to transform our understanding of RNA’s role in our growth and development, and provide a new avenue for treating infectious diseases and cancer.”
Prof. Feng Zhang has been named a recipient of the 2016 Canada Gairdner International Award for his work on the development of the CRISPR gene-editing system, reports CBC News. CRISPR "may prove to be a ‘powerful therapeutic’ for treating human diseases by editing out harmful genetic mutations.”
Globe and Mail reporter Ivan Semeniuk spotlights Prof. Feng Zhang and his role in developing the CRISPR-Cas9 gene-editing system, for which he was honored as a recipient of the 2016 Canada Gairdner International award. “CRISPR genome editing technology is a really powerful platform,” says Zhang. “It think it will advance both our ability to understand disease and to develop treatments.”
MIT researchers have found a possible link between attention deficit disorders and autism, reports Lindsay Kalter for The Boston Herald. “One of the long-term goals is gene therapy where we can actually introduce genetic material that might be missing from the human,” explains grad. student Michael Wells.