Imaging

Schematic illustration of probe adsorption influenced by an attractive interaction within the corona

SMART discovers nondisruptive way to characterize the surface of nanoparticles

New method overcomes limitations of existing chemical procedures and may accelerate nanoengineering of materials.

November 12, 2019

ArtGut has three chambers: At the top is a gas cap through which nitrogen diffuses via a rubber membrane to the sample chamber below, generating a steep oxygen gradient that mimics conditions in the human gut, and the chamber at bottom emulates the gut's mucus lining.

Ten Lincoln Laboratory technologies earn 2019 R&D 100 Awards

International awards recognize innovations that can have significant impacts on society.

November 4, 2019

A new type of polymer designed by MIT chemists incorporates a special monomer (yellow) that helps the polymers to break down more easily under certain conditions.

New synthesis method yields degradable polymers

Materials could be useful for delivering drugs or imaging agents in the body; may offer alternative to some industrial plastics.

October 28, 2019

“The major research directions and technology platforms that [my] lab is known for today came out of this process where the students or I had a crazy idea, and then the lab executed on it, with all the twists and turns along the way,” says Paul Blainey, associate professor of biological engineering.

Biological engineer Paul Blainey creates new tools to advance biomedical research

His technology platforms have benefited genomics, diagnostics, and drug screening.

October 19, 2019

In situ sequencing identifies the gene knockout in each cell of a pooled CRISPR library. Fluorescence microscopy records both cellular phenotypes and sequencing data (cell nuclei are depicted in gray and the nucleotide bases are green = guanine, red = thymine, magenta = adenine and cyan = cytosine).

Imaging combined with genetic screening of cells enhances genomic discoveries

New image-based genetic screening method helps researchers identify key regulators of inflammation.

October 17, 2019

A novel model developed at MIT recovers valuable data lost from images and video that have been “collapsed” into lower dimensions. It can, for instance, recreate video from motion-blurred images or from cameras that capture people’s movement around corners as vague one-dimensional lines.

Recovering “lost dimensions” of images and video

Model could recreate video from motion-blurred images and “corner cameras,” may someday retrieve 3D data from 2D medical images.

October 16, 2019

Lincoln Laboratory employees (left to right) William Moulder, Jayme Selinger, David Pronchick, and Jeffrey Herd accept the FLC Excellence in Technology Transfer Award.

Technology transfer award recognizes system that detects concealed objects on people

The technology, first developed at Lincoln Laboratory, is now licensed and will soon be tested to screen passersby in sports stadiums.

October 4, 2019

An algorithm developed at MIT takes MRI images of placentas (top) and flattens them to be more easily analyzed (middle and bottom).

Using algorithms to build a map of the placenta

New technique stretches out MRI scans of placentas so they can be more accurately analyzed, and shows the potential of MRI for pregnancy monitoring.

October 2, 2019

Researchers at MIT and the Broad Institute of MIT and Harvard have devised a new way to rapidly image synaptic proteins at high resolution. Using fluorescent nucleic acid probes, they can label and image as many as 12 different proteins in neuronal samples containing thousands of synapses.

Technique can image individual proteins within synapses

Rapid imaging method could help reveal how conditions such as autism affect brain cells.

September 26, 2019

A visualization of the data for a sample provided by DNA microscopy, with random colors assigned to individual inferred cells.

A chemical approach to imaging cells from the inside

Researchers develop a new microscopy system for creating maps of cells, using chemical reactions to encode spatial information.

June 20, 2019

MIT researchers have developed a system that gleans far more labeled training data from unlabeled data, which could help machine-learning models better detect structural patterns in brain scans associated with neurological diseases. The system learns structural and appearance variations in unlabeled scans, and uses that information to shape and mold one labeled scan into thousands of new, distinct...

From one brain scan, more information for medical artificial intelligence

System helps machine-learning models glean training information for diagnosing and treating brain conditions.

June 19, 2019

Researchers at MIT and MGH have developed an image-guided surgical system that could help surgeons better visualize and remove tiny ovarian tumors. Fluorescent carbon nanotubes are used as probes to bind to the tumors, making them easier to see.

Imaging system helps surgeons remove tiny ovarian tumors

More effective surgery could boost survival rates for ovarian cancer.

April 23, 2019

MIT researchers have developed a new technique using quantum reference beacons for superresolution optical focusing in complex media.

Technique could boost resolution of tissue imaging as much as tenfold

Approach developed by MIT engineers surmounts longstanding problem of light scattering within biological tissue and other complex materials.

January 31, 2019

MIT chemists have enhanced the resolution of nuclear magnetic resonance (NMR), which should allow more rapid and detailed study of proteins such as the beta amyloid protein that accumulates in the brains of Alzheimer’s patients.

Enhanced NMR reveals chemical structures in a fraction of the time

Technique could yield insights into complex proteins involved in Alzheimer’s and other diseases.

January 18, 2019

A 3-D rendering of mouse visual cortex stretching from the surface at left to the subplate on the right. The green color represents calcium signals of neural activity and magenta represents blood vessels and myelin fibers in the white matter.

Scope advance gives first look through all cortical layers of the awake brain

Substantial refinements of three-photon microscopy allow for novel discoveries in neuroscience.

January 11, 2019

MIT News | Massachusetts Institute of Technology

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