Health

Prof. Linda Griffith and Stuart Orkin '67 were named to this year’s Time 100 Health list, which recognizes innovators leading the way to new health solutions. Griffith, who was honored for her work engineering a uterine organoid to study endometriosis, explains that in the future engineered organoids could be used to find the most effective treatments for patients. “We have all the genetic information and all the information from the patient’s exposure to infections, environmental chemicals, and stress that would cause the tissues to become deranged in some way, all captured in that organoid,” Griffith explains. 

Researchers at MIT have developed a new measure called “outdoor days,” which describes the number of days per year in which temperatures are comfortable enough for outdoor activities in specific locations around the world, reports Lebawit Lily Girma for Bloomberg News. “Changes in the number of outdoor days will impact directly how people around the world feel climate change,” says Prof. Elfatih Eltahir.

MIT researchers have developed a new tool to quantify how climate change will impact the number of “outdoor days” where people can comfortably spend time outside in specific locations around the world, reports Tim DeChant for TechCrunch. “The MIT tool is a relatable application of a field of study known as climate scenario analysis, a branch of strategic planning that seeks to understand how climate change will impact various regions and demographics,” writes De Chant.

MIT researchers have found that “when an AI tool for radiologists produced a wrong answer, doctors were more likely to come to the wrong conclusion in their diagnoses,” report Daniel Payne, Carmen Paun, Ruth Reader and Erin Schumaker for Politico. “The study explored the findings of 140 radiologists using AI to make diagnoses based on chest X-rays,” they write. “How AI affected care wasn’t dependent on the doctors’ levels of experience, specialty or performance. And lower-performing radiologists didn’t benefit more from AI assistance than their peers.”

Bloomer Tech, a health tech startup founded by Alicia Chong Rodriguez SM ‘17, SM ’18, is working to “address the gender gap in health care, which has led to less clinical trial representation and fewer resources to diagnose and treat women with various diseases,” reports Steph Solis for Axios. The startup is prepared “to launch a clinical trial for bras that could help detect heart irregularities and other conditions that can lead to heart disease,” writes Solis.

Researchers from MIT and elsewhere are studying how T-cell receptors recognize antigens, reports Michael T. Nietzel for Forbes. The team “hopes to develop antigen-specific immunotherapies which could also have treatment implications for infectious diseases and allergies,” writes Nietzel.

Research scientist Beth Pollack speaks with the New York Times’ Pam Belluck about her work studying the mechanisms of long Covid-19 and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). “Experts said the study, which is the N.I.H’s first detailed look at ME/CFS, should be considered only one step in understanding the condition, its severity and potential remedies,” explains Belluck. “We must advance the field towards research on treatment,” says Pollack.

Prof. Jonathan Weissman and his colleagues have developed a new tool for monitoring changes in human blood cells, which could one day help researchers predict disease risk, reports Megan Molteni for STAT. “The technology paves the way for a day in the not too distant future where it is conceivable that from a simple blood draw, a doctor could get a sense of what’s going on in that patient’s bone marrow,” writes Molteni, “picking up perturbations there that could help predict a diverse range of diseases.”

Popular Mechanics reporter Jill Waldbieser spotlights Prof. Hugh Herr and his work developing prosthetic limbs that integrate with their human hosts using a surgical technique that preserves the sensation in artificial limbs. “In the future, on the order of five years or so, we’ll be so good at this, we’ll completely restore the signals from the prosthetic to the brain and from the brain to the prosthetic, like the limb was never amputated,” says Herr.

Smithsonian Magazine reporter Sarah Kuta spotlights MIT researchers and their work in developing an ingestible vibrating pill that simulates the feeling of being full. The device “could someday offer an obesity treatment that doesn’t rely on standard medications or surgery,” writes Kuta.

MIT researchers have created a vibrating capsule that can send signals to the brain to simulate the sensation of being full, reports Brian Heater for TechCrunch. “The capsule, which is roughly the size of a standard multi-vitamin, contains a vibrating motor, powered by a silver oxide battery,” explains Heater. “After reaching the stomach, gastric acid dissolves the outside layer and completes the circuit, kickstarting the vibration.”

Researchers at MIT have developed a vibrating pill that “significantly reduces food consumption by mimicking the feeling of fullness,” reports Arianna Johnson for Forbes. Researchers believe, “the pill can be used as a cheaper, noninvasive option to treat obesity and other weight-related illnesses,” writes Johnson.

Writing for STAT, Prof. Joseph Doyle addresses new research that suggests food “as medicine can improve health and lower health care costs.” “Researchers, clinicians and policymakers all share a common goal to fight food insecurity and improve population health,” writes Doyle. “Randomized clinical trials are key tools for discerning what works best, for whom and why, information that we should all be hungry for.”

MIT researchers have created “a vibrating pill that stimulates nerve endings in the stomach to tell the brain it’s time to stop eating,” reports Mitch Leslie for Science. “A gel plug in the pill keeps the motor from switching on,” explains Leslie. “But the gel dissolves rapidly when it contacts stomach fluid, allowing the motor to start turning. When that happens, the pill shakes for about 38 minutes, roughly the amount of time it would stay in the stomach. The researchers hypothesized that these vibrations would stimulate the stretch-sensing nerve endings and signal satiety.”

Newsweek reporter Pandora Dewan spotlights MIT researchers and their work developing an ingestible vibrating pill that can mimic the sensation of fullness. "The development of new non-invasive methods for treating obesity is of importance in confronting the multifaceted challenges posed by this global health crisis," says Shriya Srinivasan PhD ’20. "Traditional interventions, such as invasive surgeries, can be associated with significant risks, costs and lifestyle modifications, limiting their applicability and effectiveness.”