Prof. William Thilly, a “leader of groundbreaking research into human genetic mutations, Massachusetts Institute of Technology professor, and the inventor of Kellogg’s Apple Jacks cereal,” has died at age 79, reports Jade Lozada for The Boston Globe. “I will always remember Bill as my first mentor and a scientific father figure,” says alumnus Tushar Kamath. “I can’t imagine having pursued a career of medical research without the formative experiences he offered me.”
The 2024 Nobel Prize in Physiology or Medicine has been awarded to Victor Ambros '75, PhD '79 and Gary Ruvkun for the discovery of microRNA, “a tiny class of RNA molecules that play a crucial role in determining how organisms mature and function – and how they sometimes malfunction,” reports Teddy Rosenbluth and Derrick Bryson Taylor for The New York Times. Ambros and Ruvkun “had been postdoctoral fellows at the same time at Massachusetts Institute of Technology,” they explain . “As they studied C. elegans, they at first felt a smidgen of friendly competition as they each started their own labs in the Boston area, Dr. Ambros said.”
Victor Ambros '75, PhD '79 and Gary Ruvkun have won the 2024 Nobel Prize in Physiology or Medicine for the discovery of microRNAs, report Mark Johnson and Lizette Ortega for The Washington Post. “Ambros and Ruvkunhad worked together as postdoctoral researchers in the lab of Nobel laureate and MIT Professor Robert Horvitz. “What the microRNAs really end up revealing for us is a way that parts of our genome can communicate with other parts of the genome,” says Ambros. “The significance of this discovery of microRNAs is that it allowed us to be aware of a very complex and nuanced layer of regulation whereby genes in our cells talk to each other.”
Victor Ambros ‘75, PhD ‘79 and Gary Ruvkun have won the 2024 Nobel Prize in Physiology or Medicine for “their groundbreaking work on how genes behave,” reports Patrick Smith for NBC News. Ambros and Ruvkun, who worked as postdocs in the lab of Professor H. Robert Horvitz in the late 1980s, discovered how microRNA molecules play a key role in gene regulation. "The pair sought to explore how nerve cells and muscle cells, for example, have very different characteristics despite having the same genetic information," writes Smith.
The Boston Globe’s Angelina Parrillo interviews Jasmina Aganovic ’09 about her beauty company Arcaea, which reconstructs data from extinct flowers to produce fragrances. “I viewed fragrance as this remarkable emotional storytelling category and people don’t view science as being associated with creativity, emotion, or storytelling,” Aganovic says. “I think that that’s very far from the truth.”
Prof. Li-Huei Tsai, director of the Picower Institute, speaks with NPR host Jon Hamilton about her work identifying a protein called reelin that appears to protect brain cells from Alzheimer's. “Tsai says she and her team are now using artificial intelligence to help find a drug that can replicate what reelin does naturally,” says Hamilton.
Prof. Emerita Mary-Lou Pardue, a cellular and molecular biologist whose work “formed the foundation for key advancements and discoveries in understanding the structure of chromosomes,” has died at age 90, reports Bryan Marquard for The Boston Globe. Pardue “was a role model of what women in science can be at a time when there weren’t a lot of those, and a trailblazer as a woman,” emphasizes Ky Lowenhaupt, manager of the Biophysical Instrumentation Facility at MIT, “but also a trailblazer as a scientist who didn’t do things along the path that other people took.”
Sonia Vallabh and Eric Minikel, senior group leaders from the Broad Institute have created a gene-editing tool to combat prion diseases, reports Karen Weintraub for USA Today. The approach “should also work against diseases such as Huntington's, Parkinson's, ALS and even Alzheimer's, which result from the accumulation of toxic proteins,” Weintraub writes.
MIT researchers have created an amber-like material that preserves DNA so it can store data, improving on current methods that use particles of silica or require freezing, reports Pandora Dewan for Newsweek. The team “demonstrated their material by embedding and subsequently removing a DNA sequence encoding the music for the Jurassic Park theme song,” Dewan explains. “Following this process, they sequenced the molecule and confirmed that no errors had been introduced into the DNA sequence.”
MIT researchers have discovered a protein found in human sweat that holds antimicrobial properties and can “inhibit the growth of the bacteria that causes Lyme disease,” reports Matt Fortin for NENC. The team believes this “type of protein could be put into a topical cream to make something called ‘Lyme Block’ – like sunblock, but for preventing Lyme.” "Ideally what we would love to do is give people more control over their own risk," says Principal Research Scientist Michal Tal. "And really try to develop this into a possible preventative that you could put on repellant or sunblock to protect against other elements of the outdoors that you could also protect yourself against Lyme."
Researchers from MIT and elsewhere have isolated a “protein in human sweat that protects against Lyme disease,” reports Matthew Rozsa for Salon. The researchers believe that if “properly harnessed the protein could form the basis of skin creams that either prevent the disease or treat especially persistent infections,” writes Rosza.
MIT researchers have “used an algorithm to sort through millions of genomes to find new, rare types of CRISPR systems that could eventually be adapted into genome-editing tools,” writes Sara Reardon for Nature. “We are just amazed at the diversity of CRISPR systems,” says Prof. Feng Zhang. “Doing this analysis kind of allows us to kill two birds with one stone: both study biology and also potentially find useful things.”
Ashley Smart, associate director of the Knight Science Journalism Program, writes for Undark about the impact of commercialized genetic tests on research involving new genetic links. “Even among some researchers who are optimistic about using polygenic scores to screen for physical health conditions, there is one emerging application of polygenic scores that makes them uneasy: the prediction of risks for depression and other psychiatric conditions,” writes Smart.
Researchers at MIT and elsewhere have identified key cell types that may protect the brain against Alzheimer’s symptoms, reports Sara Reardon for Nature. “Most Alzheimer’s research has focused on excitatory neurons, which relay electrical signals to activate other neurons,” explains Reardon. “But the authors found that the cells with reelin or somatostatin were inhibitory neurons, which halt neuronal communication. These inhibitory cells might therefore have a previously unknown role in the types of cognitive function that are lost during Alzheimer’s.”
Writing for The Washington Post, research affiliate Bina Venkataraman emphasizes that “if biomedical breakthroughs are to benefit the millions of children afflicted with rare diseases, genetic testing of babies needs to expand.” Venkataraman adds: “By screening newborn genomes for currently known genetic diseases, patients and scientists could gain insights that lead to the treatment and prevention of thousands of illnesses that currently lack cures.”