![“The major research directions and technology platforms that [my] lab is known for today came out of this process where the students or I had a crazy idea, and then the lab executed on it, with all the twists and turns along the way,” says Paul Blainey, associate professor of biological engineering.](/sites/default/files/styles/term_page__news_article/public/images/201910/MIT-Blainey.jpg?itok=sTavLw_j)
Biological engineer Paul Blainey creates new tools to advance biomedical research
His technology platforms have benefited genomics, diagnostics, and drug screening.
Imaging combined with genetic screening of cells enhances genomic discoveries
New image-based genetic screening method helps researchers identify key regulators of inflammation.
Understanding genetic circuits and genome organization
Assistant professors Pulin Li and Seychelle Vos are investigating how cells become tissues and the proteins that organize DNA.
A comprehensive catalogue of human digestive tract bacteria
Researchers identify nearly 8,000 strains of bacteria, while also clarifying their genetic and metabolic context.
Using CRISPR to program gels with new functions
Smart materials change properties in response to specific DNA sequences; could be used in a variety of devices.
An emerging view of RNA transcription and splicing
Whitehead Institute scientists find chemical modification contributes to trafficking between non-membrane-bound compartments that control gene expression.
Study furthers radically new view of gene control
Along the genome, proteins form liquid-like droplets that appear to boost the expression of particular genes.
A new way to block unwanted genetic transfer
Researchers identify a strategy to prevent mobile genetic elements from breaching the bacterial cell wall.
Speeding up drug discovery for brain diseases
Whitehead Institute team finds drugs that activate a key brain gene; initial tests in cells and mice show promise for rare, untreatable neurodevelopmental disorder.
Neuroscientists identify brain region linked to altered social interactions in autism model
In a mouse model, restoring activity of a specific forebrain region reverses social traits associated with autism.
Uncovering the riches of traditional global medicine
Researchers solve how the kava plant produces its pain-relieving and anti-anxiety molecules, demonstrate an extensible method to scale and optimize production.
Genetic study takes research on sex differences to new heights
Differences in male and female gene expression, including those contributing to height differences, found throughout the body in humans and other mammals.
New CRISPR platform expands RNA editing capabilities
The new system, dubbed RESCUE, allows RNA edits to be made that were not previously possible.
Record-breaking DNA comparisons drive fast forensics
Developed at MIT Lincoln Laboratory, IdPrism and its award-winning algorithms provide rapid analysis for complex forensic DNA samples.
New gene-editing system precisely inserts large DNA sequences into cellular DNA
Researchers identify and develop new CRISPR-associated transposase system for targeted integration of DNA, adding key capabilities to gene-editing technology.