Lloyd Mallinson reports for Boston.com that researchers from MIT and Harvard have discovered the link between obesity and genetics. “The uncovered cellular circuits may allow us to dial a metabolic master switch for both risk and non-risk individuals, as a means to counter environmental, lifestyle, or genetic contributors to obesity,” explains Prof. Manolis Kellis.
Prof. Manolis Kellis speaks with BBC reporter Andrew Peach about the discovery of a genetic “master switch” inside fat cells. This switch “decides whether every time we have a meal the excess calories will be stored as fat or whether they will actually be burned away as heat,” explains Kellis.
Prof. Manolis Kellis and his colleagues have discovered a metabolic switch linked to obesity, reports Chukwuma Muanya for The Guardian. “Obesity has traditionally been seen as the result of an imbalance between the amount of food we eat and how much we exercise, but this view ignores the contribution of genetics to each individual’s metabolism,” explains Kellis.
“Researchers at MIT and Harvard Medical School have analysed the genetics behind obesity,” writes Natasha Hinde for The Huffington Post. “They discovered a new pathway that controls human metabolism by prompting fat cells to store fat or burn it away.”
Andy Coghlan reports for New Scientist that MIT researchers have found a gene that determines whether fat cells store or burn energy. “You could say we’ve found fat cells’ radiator, and how to turn it up or down,” says Prof. Manolis Kellis.
Alice Park reports for TIME that researchers from MIT and Harvard have identified a pathway that controls how much fat cells burn or store. “What these results say is that we can reprogram all the major fat stores in humans by intervening in this particular pathway,” explains Prof. Manolis Kellis.
Researchers from MIT and Harvard have discovered how the key gene linked to obesity makes people fat, reports the Associated Press. The study revealed that “a faulty version of the gene causes energy from food to be stored as fat rather than burned.”
Boston Globe reporter Kevin Hartnett writes that MIT researchers have shown it is impossible to create a faster version of the “edit distance” algorithm, which is used to compare the genomes of different species. Hartnett writes that the finding “has been greeted with something like relief among computer scientists.”
Kathleen McKenna of The Boston Globe writes that Professor Alexander Rich, whose research confirmed DNA’s double-helix structure, died at 90 on April 27. Shuguang Zhang, associate director of the Center for Biomedical Engineering at MIT, said that Rich was “warm, wonderful, and open-minded.”
Washington Post reporter Martin Weil writes that Prof. Alexander Rich, who was known for his work with molecular biology, passed away on April 27. Rich’s work on hybridization, the pairing of two single strands of DNA or RNA, “is regarded as integral to creating much of modern biotechnology, with applications in diagnostics, forensics, genealogy and gene sequencing.”
Prof. Alexander Rich, a noted biophysicist known for his work investigating the structure of DNA and RNA, died on April 27, writes Denise Gellene for The New York Times. “I can think of no one else who has made as many major contributions to all facets of modern molecular biology,” said University of Maryland Prof. Robert C. Gallo.
Sarah Hedgecock writes for Forbes about how researchers have made major advances in mapping the human epigenome. Prof. Manolis Kellis explains that the new findings allow researchers to “ go from a static picture of the genome, which is effectively the book of life, to a dynamic picture of a genome.”
A team of researchers has published a map of the human epigenome, which could be useful in better understanding how to treat disease, writes Amanda Schupak for CBS News. Prof. Manolis Kellis explains that the findings provide “a reference for studying the molecular basis of human disease, by revealing the control regions that harbor genetic variants associated with different disorders."
Marcus Woo writes for Wired about how researchers have published a number of articles providing new information on the human epigenome, which controls which genes get switched on or off. “It is giving us a view of the living, breathing genome in motion, as opposed to a static picture of DNA,” explains Prof. Manolis Kellis.
Rachel Feltman of The Washington Post reports that a team led by Professor Manolis Kellis has released the most complete map of the human epigenome to date. “The researchers tied specific cell changes to 58 different biological traits,” writes Feltman. “Sometimes the epigenomic changes of a cell reveal possible clues about disease.”