Using CRISPR as a research tool to develop cancer treatments
KSQ Therapeutics uses technology created at MIT to study the role of every human gene in disease biology.
An on-off switch for gene editing
New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.
Seeking the cellular mechanisms of disease, with help from machine learning
Caroline Uhler blends machine learning, statistics, and biology to understand how our bodies respond to illness.
A safer way to deploy bacteria as environmental sensors
Encapsulating modified bacteria in tough hydrogel spheres prevents them from spreading genes to other microbes.
How industrialized life remodels the microbiome
International study reveals gut bacteria from people in industrialized societies swap genes at much higher rates.
Study: One enzyme dictates cells’ response to a probable carcinogen
Varying levels of a DNA repair enzyme can lead to very different outcomes after exposure to NDMA.
Eyeless roundworms sense color
C. elegans compares the ratio of wavelengths in its environment to avoid dangerous bacteria that secrete colorful toxins.
Study offers an explanation for why the APOE4 gene enhances Alzheimer’s risk
The gene variant disrupts lipid metabolism, but in cell experiments the effects were reversed by choline supplements.
MIT team improving gene therapies wins Sloan health care prize
Kano Therapeutics was one of eight finalists to pitch at the virtual competition.
Basic cell health systems wear down in Huntington’s disease, analysis shows
A new computational approach for analyzing complex datasets shows that as disease progresses, neurons and astrocytes lose the ability to maintain homeostasis.
Amy Jin named 2021 Gates Cambridge Scholar
MIT senior will pursue graduate studies at Cambridge University.
Metabolic mutations help bacteria resist drug treatment
Study suggests forcing bacteria to burn more energy could make them more susceptible to antibiotics.
Robert Weinberg receives 2021 Japan Prize
The award recognizes Weinberg’s pioneering achievements in the field of cancer biology.
Epigenomic map reveals circuitry of 30,000 human disease regions
Analysis reveals genetic control elements that are linked to hundreds of human traits.
A high-resolution glimpse of gene expression in cells
Expanding tissue samples before sequencing allows researchers to pinpoint locations of RNA molecules.