Drug development

Barbara Imperiali, Class of 1922 Professor of Biology and professor of chemistry

Probing the function of key proteins

Professor Barbara Imperiali creates better biochemical tools for basic biology and drug development.

January 12, 2017

MIT spinout Benchling is bringing life science researchers a cloud-based platform that integrates different types of lab software into one place, with aims of making research and development easier, quicker, and more collaborative.

“Google Docs” for life sciences accelerates discovery

Cloud-based platform assists in managing, sharing data facilitates research.

December 7, 2016

Molecular fMRI data showing signal changes from serotonin sensors in the absence (left) and presence (right) of the antidepressant Prozac, with each square denoting an individual brain voxel. Red squares indicate the signal has increased, as more serotonin is absorbed into neurons; blue squares indicate the signal has decreased, as less serotonin is absorbed into neurons. Dotted and solid lines gr...

Mapping serotonin dynamics in the living brain

Imaging technique that creates 3-D video of serotonin transport could aid antidepressant development.

October 20, 2016

3Q: Berhardt Trout on spurring innovation in drug manufacturing

From EpiPen pricing to government oversight, the making of medicine impacts all aspects of modern health care.

September 23, 2016

Researchers at MIT and other institutions have created tiny freeze-dried pellets that include all of the molecular machinery needed to translate DNA into proteins, which could form the basis for on-demand production of drugs and vaccines.

To produce biopharmaceuticals on demand, just add water

Freeze-dried cellular components can be rehydrated to churn out useful proteins.

September 22, 2016

A team of MIT scientists has developed a strategy for delivering large numbers of beneficial bacterial to the human gut. The strategy involves coating bacteria with polymer layers that protect them from the acids and bile salts found in the digestive tract.

Delivering beneficial bacteria to the GI tract

Method that transports microbes through the stomach to the intestine may benefit human health.

September 14, 2016

A new technique invented at MIT can precisely measure the growth of many individual cells simultaneously. “The device provides new insights into how cells grow and respond to drugs,” MIT professor Scott Manalis says.

Microchip enables fast, precise measurement of single-cell growth

Device that measures growth of many individual cells simultaneously could lead to rapid tests for antibiotics.

September 5, 2016

Researchers at MIT have for the first time identified the structure of class I fumarate hydratase enzyme, which could be a target for drugs combatting diseases prevalent in the developing world.

Targeting neglected diseases

New enzyme-mapping advance could help drug development.

August 15, 2016

A research team led by MIT chemistry professor Mohammad Movassaghi has developed a strategy for synthesizing a group of compounds called communesins, which occur naturally in some fungi. Researchers may now be able to further investigate the compounds’ cancer-fighting abilities. Pictured is an image of penicillium fungus.

A new approach to chemical synthesis

Communesins, originally found in fungus, could hold potential as cancer drugs.

June 7, 2016

This device built by MIT researchers can be reconfigured to manufacture several different types of pharmaceuticals.

Pharmacy on demand

New, portable system can be configured to produce different drugs.

March 31, 2016

CEO Justin Lamb says Genometry aims to help pharmaceutical firms use gene-expression data (represented here as a heat map of gene expression values) to effectively digitize their compound collections.

Faster drug discovery?

Startup develops more cost-effective test for assessing how cells respond to chemicals.

January 28, 2016

This scanning electron micrograph depicts spores of Bacillus anthracis bacteria magnified to more than 12,000 times their actual size.

Chemists recruit anthrax to deliver cancer drugs

With some tinkering, a deadly protein becomes an efficient carrier for antibody drugs.

September 24, 2014

MIT chemists have devised a way to rapidly combine amino acids into protein fragments known as peptides.

Fast synthesis could boost drug development

Chemists devise a new way to manufacture peptide drugs, which hold promise for treating many diseases.

March 18, 2014

Conversations on sociotechnical systems

Seminar will focus on technological platforms for on-demand biopharmaceutical manufacturing

February 28, 2014

Marrying tissue engineering with systems biology

Linda Griffith combines in vitro models with deep molecular analysis to accelerate drug discovery.

January 31, 2014

MIT News | Massachusetts Institute of Technology

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