Drug delivery

“We are very excited about this work because, for the first time, we can create a library of tiny, encased vaccine particles, each programmed to release at a precise, predictable time,” says professor Robert Langer.

One vaccine injection could carry many doses

Microparticles created by new 3-D fabrication method could release drugs or vaccines long after injection.

September 14, 2017

A phase diagram of living mammalian cytoplasm, developed by MIT researchers, describes the type of material an organelle feels as it moves through cytoplasm, given its size and speed.

How cytoplasm “feels” to a cell’s components

In study that may guide drug design, researchers find organelles encounter varying levels of resistance.

August 21, 2017

Summer Scholar Alejandro Aponte works on a prototype for a pump that can deliver drugs to the brain. Aponte, a University of Puerto Rico at Mayaguez mechanical engineering major, is working to make the pump small enough to be easily implantable.

Prototyping a pump for brain treatment

Summer Scholar Alejandro Aponte troubleshoots the design for an implantable pump that can deliver drugs to the brain.

August 4, 2017

Jinyao Liu, left, and Giovanni Traverso stretch a new hydrogel. To help ensure patients receive their full course of treatment, researchers have developed a new set of drug delivery materials made of the hydrogel. The material can reside in the stomach for up to nine days and slowly release its dosage of medication.

Ingestible drug-delivery materials may help patients comply with treatment regimens

Hydrogel-based capsules could expand and reside in the GI tract for days, slowly releasing medication.

July 25, 2017

MIT engineers have designed a gel-like material that can be coated onto standard plastic or rubber devices, providing a softer, more slippery exterior that can significantly ease a patient’s discomfort during surgery.

New gel coatings may lead to better catheters and condoms

Bonded layers of rubber and hydrogel yield tough, slippery, and impermeable coatings.

July 18, 2017

Mark Bathe, associate professor in MIT’s Department of Biological Engineering

Deploying therapeutic payloads to cells

Mark Bathe develops molecular packages for targeted delivery of drugs, vaccines, and gene-editing tools.

June 4, 2017

Multiply Labs founders (l-r) Joe Wilson, Alice Melocchi, Tiffany Kuo, and Fred Parietti have invented a 3-D pill printing technique that creates personalized dietary supplements.

Using supplements? Order a personalized pill

Seed funding from the MIT Sandbox Innovation Fund helped Multiply Labs' founders launch their personalized dietary supplement startup.

May 1, 2017

Wireless power could enable ingestible electronics

Small sensors or drug delivery devices could reside in the GI tract indefinitely.

April 27, 2017

Researchers at MIT and Brigham and Women’s Hospital have designed and demonstrated a small, ingestible voltaic cell that is sustained by the acidic fluids in the stomach.

Engineers harness stomach acid to power tiny sensors

Ingestible electronic devices could monitor physiological conditions or deliver drugs.

February 6, 2017

MIT engineers have shown that they can use short bursts of ultrasound to efficiently deliver RNA into cells.

RNA hitches a ride on ultrasound waves

Technique enables rapid delivery of RNA to treat colon inflammation.

January 20, 2017

MIT postdoc Carl Schoellhammer (center) takes home gold at the Collegiate Inventor’s Competition for his SuonoCalm system.

Carl Schoellhammer wins gold medal at 2016 National Collegiate Inventors Competition

MIT postdoc honored for his work developing a technique to quickly deliver medicine to the gastrointestinal tract.

December 15, 2016

The star-shaped drug delivery device, held here by Giovanni Traverso, a Koch Institute research affiliate, can be folded inward and encased in a smooth capsule. Once ingested, the device delivers a full drug payload gradually over weeks or even months.

New capsule achieves long-term drug delivery

Technology could aid in elimination of malaria and treatment of many other diseases.

November 16, 2016

Paula Hammond, the David H. Koch Professor in Engineering and head of MIT’s Department of Chemical Engineering, has been elected to the National Academy of Medicine in recognition of her distinguished contributions to medicine and health.

Paula Hammond elected to the National Academy of Medicine

Chemical engineer recognized for her contributions to medicine and health.

October 17, 2016

MIT researchers have developed a stretchy optical fiber in which they have injected multiple organic dyes (yellow, blue, and green regions). In addition to lighting up, the dyes act as a strain sensor, enabling researchers to quantify where and by how much a fiber has been stretched.

Stretchy optical fibers for implanting in the body

Biocompatible fibers could use light to stimulate cells or sense signs of disease.

October 17, 2016

A new gene therapy technique being developed by researchers at MIT uses microRNAs — small noncoding RNA molecules that regulate gene expression — to control breast cancer metastasis.

Gene therapy technique may help prevent cancer metastasis

Gene-regulating RNA molecules could help treat early-stage breast cancer tumors before they spread.

September 19, 2016

MIT News | Massachusetts Institute of Technology

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