DNA

MIT researchers have developed a technique to use a damage suppressing protein called “Dsup” to help protect cancer patients from the side effects of radiation therapy, writes Shane Galvin for The New York Post. “Scientists, encouraged by this remarkable discovery, believe they can create an upgraded version of Dsup which can be used to radiation-proof human cells without any unwanted drawbacks,” writes Galvin. “They also believe that the protein could be used by astronauts to prevent space-related radiation [damage].” 

Researchers at MIT and elsewhere have found that a protein developed by tardigrades could be used to help protect cancer patients from the side effects of radiation therapy, reports Ed Cara for Gizmodo. “The findings could someday lead to an invaluable add-on treatment for many cancer patients,” writes Cara. He adds that the new technique “could even possibly be used to protect astronauts from space-related radiation or to protect cancer patients from other sources of treatment-induced DNA damage, such as chemotherapy drugs.”

According to a new study co-authored by researchers at MIT, harnessing the damage suppressor protein found in tardigrades, a microscopic organism known for its resilience, could help ease the impacts of radiation therapy on cancer patients. “The Dsup protein, which binds directly to DNA and reduces radiation-induced strand breaks, immediately struck us as a promising tool to mitigate normal tissue injury during radiotherapy,” Prof. Giovanni Traverso explains to Corinna Singleman of Genetic Engineering & Biotechnology News. 

New York Times reporter Eric Lipton spotlights Prof. Christopher Voigt and his team’s “radical effort to engineer nature to fight climate change” by creating genetically modified bacteria to help reduce the use of chemical fertilizers. Lipton notes that Voigt is “a rock star of sorts in the fast-growing field of biological engineering.” 

The 2024 Nobel Prize in Physiology or Medicine has been awarded to Victor Ambros '75, PhD '79 and Gary Ruvkun for the discovery of microRNA, “a tiny class of RNA molecules that play a crucial role in determining how organisms mature and function – and how they sometimes malfunction,” reports Teddy Rosenbluth and Derrick Bryson Taylor for The New York Times. Ambros and Ruvkun “had been postdoctoral fellows at the same time at Massachusetts Institute of Technology,” they explain . “As they studied C. elegans, they at first felt a smidgen of friendly competition as they each started their own labs in the Boston area, Dr. Ambros said.”

Victor Ambros '75, PhD '79 and Gary Ruvkun have won the 2024 Nobel Prize in Physiology or Medicine for the discovery of microRNAs, report Mark Johnson and Lizette Ortega for The Washington Post. “Ambros and Ruvkunhad worked together as postdoctoral researchers in the lab of Nobel laureate and MIT Professor Robert Horvitz. “What the microRNAs really end up revealing for us is a way that parts of our genome can communicate with other parts of the genome,” says Ambros. “The significance of this discovery of microRNAs is that it allowed us to be aware of a very complex and nuanced layer of regulation whereby genes in our cells talk to each other.”

Victor Ambros ‘75, PhD ‘79 and Gary Ruvkun have won the 2024 Nobel Prize in Physiology or Medicine for “their groundbreaking work on how genes behave,” reports Patrick Smith for NBC News. Ambros and Ruvkun, who worked as postdocs in the lab of Professor H. Robert Horvitz in the late 1980s, discovered how microRNA molecules play a key role in gene regulation. "The pair sought to explore how nerve cells and muscle cells, for example, have very different characteristics despite having the same genetic information," writes Smith.

The Boston Globe’s Angelina Parrillo interviews Jasmina Aganovic ’09 about her beauty company Arcaea, which reconstructs data from extinct flowers to produce fragrances. “I viewed fragrance as this remarkable emotional storytelling category and people don’t view science as being associated with creativity, emotion, or storytelling,” Aganovic says. “I think that that’s very far from the truth.”

MIT researchers have created an amber-like material that preserves DNA so it can store data, improving on current methods that use particles of silica or require freezing, reports Pandora Dewan for Newsweek. The team “demonstrated their material by embedding and subsequently removing a DNA sequence encoding the music for the Jurassic Park theme song,” Dewan explains. “Following this process, they sequenced the molecule and confirmed that no errors had been introduced into the DNA sequence.”

Writing for STAT, Prof. Kevin Esvelt explores how, “the immense potential benefits of biotechnology are profoundly vulnerable to misuse. A pandemic caused by a virus made from synthetic DNA — or even a lesser instance of synthetic bioterrorism — would not only generate a public health crisis but also trigger crippling restrictions on research.” Esvelt adds: “The world has too much to gain from the life sciences to continue letting just anyone obtain DNA sufficient to cause a pandemic.” 

Prof. Ron Weiss co-founded Strand Therapeutics, a biotech company developing mRNA therapies, reports Emily Mullin for Wired. “The notion is that genetic circuits can really have significant impact on safety and efficacy,” says Weiss. “This begins to really open up the door for creating therapies whose sophistication can match the underlying complexity of biology.”

MIT researchers have “used an algorithm to sort through millions of genomes to find new, rare types of CRISPR systems that could eventually be adapted into genome-editing tools,” writes Sara Reardon for Nature. “We are just amazed at the diversity of CRISPR systems,” says Prof. Feng Zhang. “Doing this analysis kind of allows us to kill two birds with one stone: both study biology and also potentially find useful things.”

Jasmina Aganovic ’09 founded Future Society, a brand that uses sequenced DNA from extinct flowers to create new scents, reports Celia Shatzman for Forbes. “[With] plants that are from another time, never before have we been able to time travel through smell,” says Aganovic. “But now we can do that, thanks specifically to DNA sequencing. It’s an example of where we're starting off with this concept of limitless nature. It isn't just about stories; it's also about performance.”

Researchers at MIT and elsewhere have identified key cell types that may protect the brain against Alzheimer’s symptoms, reports Sara Reardon for Nature. “Most Alzheimer’s research has focused on excitatory neurons, which relay electrical signals to activate other neurons,” explains Reardon. “But the authors found that the cells with reelin or somatostatin were inhibitory neurons, which halt neuronal communication. These inhibitory cells might therefore have a previously unknown role in the types of cognitive function that are lost during Alzheimer’s.”

MIT researchers have discovered an RNA-guided DNA-cutting enzyme in eukaryotes, reports Science. “The researchers speculate that eukaryotic cells may have gained the newly identified editing genes from transposable elements—so-called jumping genes—they received from bacteria,” writes Science.