Prof. Richard Young and his colleagues have discovered that many transcription factors can bind RNA, reports Christie Wilcox for Science. "The team decided to investigate after scattered reports suggested that at least some transcription factors are capable of binding RNA even though they lack traditional RNA binding domains,” writes Wilcox.
MIT researchers have identified a new biological editing system that could “potentially be even more precise than CRISPR gene editing,” reports Laura Baisas for Popular Science. The new system, based on a protein called Fanzor, is “the first programmable RNA-guided system discovered in eukaryotes,” Baisas notes.
Researchers at MIT have developed a new nanoparticle sensor that can detect cancerous proteins through a simple urine test. “The researchers designed the tests to be done on a strip of paper, similar to the at-home COVID tests everyone became familiar with during the pandemic,” writes Lambert. “They hope to make it as affordable and accessible to as many patients as possible.”
Boston Globe reporter Ryan Cross spotlights Chroma Medicine, a biotech startup co-founded by MIT researchers that is “developing a new class of gene editing technologies that could control how our genetic code is read without changing the code itself.” Cross explains that Chroma Medicine’s technology could “have broad applications for treating both rare and common diseases.”
Jake Becraft PhD ’19 and former postdoctoral associate Tasuku Kitada co-founded Strand Therapeutics, a biotech firm developing mRNA therapies for cancer, reports Ryan Cross for The Boston Globe. They created “a way to activate mRNA in the presence of particular microRNAs – a much more useful application for therapies,” writes Cross.
Researchers at MIT have developed new gene-editing technology that can move large sequences of DNA into the human genome, reports Ryan Cross for The Boston Globe. “The molecular tool gives scientists a new way to completely replace broken genes, paving the way to potential cures for diseases such as cystic fibrosis,” writes Cross.
Nature reporter Neil Savage spotlights Prof. Michael Strano’s work developing a new technique to use nanoparticles to alter the biology of living plants. Savage writes that the new technique can allow for "the design of nanoparticles that carry gene-editing machinery to targeted areas to rewrite the plant’s genome and imbue it with properties such as pest and disease resistance,” writes Savage.
As a research assistant at MIT, Ai Hasegawa designed a project meant to help same-sex couples have a baby that shares both parents’ DNA, writes Jacqui Palumbo for CNN. “With progressing stem cell research and technology – such as the gene-editing technique CRISPR – it is only a matter of time,” writes Palumbo.
TechCrunch reporter Kate Park spotlights Catalog, a startup founded by MIT graduates that is “developing an energy-efficient, cost-competitive and more secure data storage and computation platform by using synthetic DNA.”
UPI reporter Brooks Hays writes that MIT researchers have developed a new technique for labeling and retrieving DNA files, “a breakthrough that could help shrink the carbon footprint of the rapidly expanding digital world.”
Research affiliate Fei Chen and his colleagues have developed a new method that could be used to uncover the organization and sequence of DNA inside intact cells, reports Nature. The new method could be used to “help to reveal how genome organization changes with disease.”
WBUR’s Carey Goldberg explores how MIT researchers developed a new CRISPR-based research tool that can be used to detect Covid-19. "A lot of things that we try fail," says research scientist Jonathan Gootenberg. "And that’s OK. Because sometimes you find these things that are really, really awesome."
Reporting for WBUR, Carey Goldberg highlights how MIT researchers have developed a new RNA editing tool that could be used to tweak a gene that raises the risk of Alzheimer’s disease. As the effects of RNA editing are not permanent, “it's almost like a small, pill-like version of gene therapy,” explains research scientist and McGovern Fellow Omar Abudayyeh.
Broad Institute postdoctoral associate Joshua Weinstein has developed a DNA microscope that allows researchers to investigate the locations and identity of DNA molecules, reports Sharon Begley for STAT. “Weinstein has so far used it to image human cancer cell lines and plans to apply the technology to tumors and the immune cells that infiltrate them,” writes Begley, “which might one day guide immunotherapy.”
STAT reporter Sharon Begley writes that Prof. Feng Zhang and his colleagues have turned “a jumping gene — aka a transposon, or mobile genetic element — into a mini TaskRabbit gig worker: With an assist from CRISPR enzymes, it zips over to the part of the genome whose address it is given and delivers a package of DNA, pronto.”