Making genetic prediction models more inclusive
MIT computer scientists developed a way to calculate polygenic scores that makes them more accurate for people across diverse ancestries.
Thousands of programmable DNA-cutters found in algae, snails, and other organisms
New research finds RNA-guided enzymes called Fanzors are widespread among eukaryotic organisms.
Decoding the complexity of Alzheimer’s disease
By analyzing epigenomic and gene expression changes that occur in Alzheimer’s disease, researchers identify cellular pathways that could become new drug targets.
Study explains why certain immunotherapies don’t always work as predicted
The findings could help doctors identify cancer patients who would benefit the most from drugs called checkpoint blockade inhibitors.
Study connects neural gene expression differences to functional distinctions
Researchers compared a pair of superficially similar motor neurons in fruit flies to examine how their differing use of the same genome produced distinctions in form and function.
Arrays of quantum rods could enhance TVs or virtual reality devices
MIT engineers developed a new way to create these arrays, by scaffolding quantum rods onto patterned DNA.
Study finds a surprising new role for a major immune regulator
In addition to turning on genes involved in cell defense, the STING protein also acts as an ion channel, allowing it to control a wide variety of immune responses.
Making sense of cell fate
MIT researchers find timing and dosage of DNA-damaging drugs are key to whether a cancer cell dies or enters senescence.
It takes three to tango: transcription factors bind DNA, protein, and RNA
Whitehead Institute researchers find many transcription factors bind RNA, which fine-tunes their regulation of gene expression, suggesting new therapeutic opportunities.
Generative AI imagines new protein structures
“FrameDiff” is a computational tool that uses generative AI to craft new protein structures, with the aim of accelerating drug development and improving gene therapy.
Focus on function helps identify the changes that made us human
A new approach for identifying significant differences in gene use between closely-related species provides insights into human evolution.
Researchers uncover a new CRISPR-like system in animals that can edit the human genome
The first RNA-guided DNA-cutting enzyme found in eukaryotes, Fanzor could one day be harnessed to edit DNA more precisely than CRISPR/Cas systems.
Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
MIT researchers characterize gene expression patterns for 22,500 brain vascular cells across 428 donors, revealing insights for Alzheimer’s onset and potential treatments.
Gene-editing technique could speed up study of cancer mutations
With the new method, scientists can explore many cancer mutations whose roles are unknown, helping them develop new drugs that target those mutations.
An unprecedented view of gene regulation
MIT engineers’ new technique analyzes the 3D organization of the genome at a resolution 100 times higher than before.