Prof. Aviv Regev speaks with the Associated Press about the Human Cell Atlas Consortium, which is aimed at cataloging all the cells in the human body in an effort to better understand human diseases. "This is not going to cure all disease immediately," she says, but "it is a critical stepping stone."
MIT researchers developed a new technique to make a more effective and precise CRISPR gene editing system, reports Eileen Drage O’Reilly for Axios. The system uses the new enzyme Cas12b, which has a “small size and precise targeting [that] will enable it to be used for in vivo applications in primary human cells,” O’Reilly explains.
Prof. Aviv Regev speaks with NPR’s Nell Greenfieldboyce about her work with the Human Cell Atlas trying to catalogue every cell in the human body. “We don't need to analyze every individual cell out of 37 trillion because the cells kind of repeat themselves,” says Regev. “All we need to do is sample enough of them from enough region in order to get comprehensive coverage.”
Writing for The Boston Globe, Prof. Eric Lander, president of the Broad Institute, argues for enabling cancer patients to become actively involved in cancer research. “Patients must have an active voice in decisions. Patient data should never be sold,” Lander writes. “Researchers anywhere should have rapid access to the de-identified clinical and genomic data, to ensure that anyone can make discoveries.”
Wired reporter Megan Molteni highlights Prof. Aviv Regev’s work leading the Human Cell Atlas, an effort to catalog the cells in the human body that could eventually serve as a roadmap for understanding and treating disease. “From the beginning we have designed this as a public good and an open resource to enable science around the world,” Regev explains.
Prof. Aviv Regev speaks with WBUR’s Karen Weintraub about her work exploring human cells. Regev says she was inspired to study the human cell as, “it’s this phenomenal entity that knows how to take many different pieces of information, make very quick and sophisticated decisions, act on them and continue on its way.”
STAT reporter Justin Chen writes about a new study that examines why patients with pancreatic cancer often experience significant weight loss. Prof. Matt Vander Heiden explains that the findings show, “pancreatic cancer patients clearly have a lot of tissue wasting and whether it’s good or bad, we can now say that it’s not necessarily bad at diagnosis.”
Professors Edward Boyden and Feng Zhang have been named to the 2018 class of Howard Hughes Medical Institute investigators, reports Jonathan Saltzman for The Boston Globe. “We selected these scientists because they know how to ask hard and interesting questions with skill and intellectual courage,” says David Clapham, vice president and chief scientific officer of the institute.
The Broad Institute of MIT and Harvard is developing a Drug Repurposing Hub, which looks to “acquire samples of every drug ever developed to see if they can be used to treat diseases besides those for which they were intended,” writes Jonathan Saltzman for The Boston Globe.
Researchers at the Broad Institute of MIT and Harvard have programmed CRISPR to “in essence, make edits when significant cellular events occur,” writes Kristin Brown for Gizmodo. “All this adds up to the potential of CRISPR as not just a gene-editing powerhouse, but a multifunctional tool that also works as a biosensor, a medical detective, and an invaluable instrument for basic research.”
A gene-editing tool called SHERLOCK, developed in Prof. Feng Zhang’s lab, allows for faster detection of infections and viruses, such as Zika and Dengue fever. “It does this by combining different types of CRISPR enzymes, which are unleashed together to target distinct bits of DNA and RNA, another of the major biological molecules found in all forms of life,” writes Alessandra Potenza for The Verge.
A new study by MIT researchers provides evidence that antibiotics can change the body’s chemistry and make it more hospitable to bacteria, reports Melinda Wenner Moyer for Scientific American. “We suspect that the strength of this effect will really depend on the type of infection and types of antibiotics used,” explains postdoc Jason Yang.
MIT scientists have developed a technique that could potentially be used one day to treat diseases of the brain, muscles, liver and kidneys by using CRISPR to edit RNA, writes Melissa Healy for The Los Angeles Times. Making edits to the chemical message of RNA, “doesn’t effect a permanent change in a cell’s architectural plan; rather, it essentially alters the implementation of that plan,” explains Healy.
Prof. Feng Zhang and his colleagues have created a CRISPR-based system that can edit RNA in human cells, reports Amy Dockser Marcus for The Wall Street Journal. “The new RNA-editing system, which the scientists have dubbed Repair, allows the editing of individual RNA letters, correcting a common mutation known to play a role in a number of diseases.”
Financial Times reporter Clive Cookson writes that Prof. Feng Zhang and his colleagues have engineered CRISPR so that it can edit single RNA letters in human cells. Cookson explains that the researchers believe that, “RNA editing offers a safer and more flexible way to make corrections than the permanent changes involved in DNA editing.”