Bacteria

Researchers have found that the hydrogel’s mostly watery environment helps keep nutrients and programmed bacteria alive and active. When the bacteria reacts to a certain chemical, the bacteria are programmed to light up, as seen on the left.

Living sensors at your fingertips

Cell-infused gloves and bandages light up when in contact with certain chemicals.

February 15, 2017

“The challenge is to engineer a system where we get enough growth to have a productive microbial ‘ chemical factory’ but not so much that we can’ t channel enough of the sugars into a pathway to make large quantities of our target molecules,”says Kristala Prather, an associate professor of chemical engineering at MIT.

Chemical engineers boost bacteria’s productivity

New technique improves yield of useful chemicals.

February 13, 2017

MIT spinout Manus Bio has created a low-cost process for engineering microbes with complex metabolic pathways borrowed from plants, which can produce an array of rare and expensive ingredients used to manufacture noncaloric beverages, perfumes, toothpastes, detergents, pesticides, and even therapeutics, among other products.

Microbial manufacturing

Engineered bacteria produce rare and commercially useful compounds in large quantities.

February 3, 2017

“Understanding how our innate immune system works is important for thinking about the development of new ways to treat infectious disease,” says MIT associate professor of chemistry Elizabeth Nolan.

Exploring the tug-of-war over metals during infection

Chemist Elizabeth Nolan studies the battle between microbes and hosts for essential metals.

January 4, 2017

MIT oceanographers have found that some small marine organisms — mostly bacteria — have a surprisingly low limit to the amount of oxygen they need to breathe.

New study sets oxygen-breathing limit for ocean’s hardiest organisms

Bacteria can survive in marine environments that are almost completely starved of oxygen.

December 19, 2016

MIT chemists have determined the structure of a bacterial enzyme that can produce biodegradable plastics, an advance that could help chemical engineers tweak the enzyme to make it even more industrially useful.

A step toward biodegradable plastics

Chemists discover structure of bacterial enzyme that generates useful polymers.

November 11, 2016

A new immunization strategy against microbes that invade the gastrointestinal tract may someday offer an alternative to antibiotics.

A new approach against Salmonella and other pathogens

Immunization strategy could prevent gastrointestinal disease.

November 7, 2016

A team of researchers at MIT, the University of Brasilia, and the University of British Columbia has now engineered an antimicrobial peptide that can destroy many types of bacteria, including some that are resistant to most antibiotics.

Engineers design a new weapon against bacteria

Antimicrobial peptides can kill strains resistant to existing antibiotics.

November 2, 2016

Manoshi Datta, a postdoc in the Department of Civil and Environmental Engineering, pipettes bacterial samples in the lab.

MIT researchers prove fast microbial evolutionary bursts exist

Study reveals closely related microbes can diversify rapidly via horizontal gene transfer.

September 22, 2016

A team of MIT scientists has developed a strategy for delivering large numbers of beneficial bacterial to the human gut. The strategy involves coating bacteria with polymer layers that protect them from the acids and bile salts found in the digestive tract.

Delivering beneficial bacteria to the GI tract

Method that transports microbes through the stomach to the intestine may benefit human health.

September 14, 2016

A new technique invented at MIT can precisely measure the growth of many individual cells simultaneously. “The device provides new insights into how cells grow and respond to drugs,” MIT professor Scott Manalis says.

Microchip enables fast, precise measurement of single-cell growth

Device that measures growth of many individual cells simultaneously could lead to rapid tests for antibiotics.

September 5, 2016

Ginkgo Bioworks staff members Ramya Prathuri (left) and Nate Tedford work at the mass spectrometer in the Ginkgo foundry.

Hacking microbes

Startup’s engineered yeast helps clients produce fragrances and flavors more efficiently.

August 25, 2016

Mars’ Valles Marineris canyon, pictured, spans as much as 600 kilometers across and delves as much as 8 kilometers deep. The image was created from over 100 images of Mars taken by Viking Orbiters in the 1970s.

New technique may help detect Martian life

A novel interpretation of Raman spectra will help the 2020 Mars rover select rocks to study for signs of life.

August 15, 2016

A new, portable production system is designed to manufacture a range of biopharmaceuticals on demand. The principal component of the microbioreactor is a plastic chip with microfluidic circuits (green), optical sensors (red and blue circles) for monitoring oxygen and acidity, and a filter to retain the cells while the therapeutic protein is extracted (white circle).

Portable device produces biopharmaceuticals on demand

System would use microbes for manufacturing small amounts of vaccines and other therapies.

July 29, 2016

Researchers at MIT and the University of California at San Diego have delivered artificial genetic circuits into bacteria, allowing the microbes to kill cancer cells in three different ways. Here, an image of a motherboard has been micropatterned using programmable probiotic bacteria. The bright lines are composed of dots made of bacteria. This technique was developed in the lab of MIT professor S...

Cancer-fighting bacteria

Engineers program E. coli to destroy tumor cells.

July 20, 2016

MIT News | Massachusetts Institute of Technology

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