Protein study could help researchers develop new antibiotics
Researchers created a water-soluble version of an important bacterial enzyme, which can now be used in drug screens to identify new antibiotics.
Researchers created a water-soluble version of an important bacterial enzyme, which can now be used in drug screens to identify new antibiotics.
SMART researchers find a cellular process called transfer ribonucleic acid (tRNA) modification influences the malaria parasite’s ability to develop resistance.
Most antibiotics target metabolically active bacteria, but with artificial intelligence, researchers can efficiently screen compounds that are lethal to dormant microbes.
These compounds can kill methicillin-resistant Staphylococcus aureus (MRSA), a bacterium that causes deadly infections.
SMART researchers find the enzyme RlmN, which directly senses chemical and environmental stresses, can be targeted in drug development.
SMART researchers combine rifaximin and clarithromycin to effectively restore the latter drug's efficacy.
The machine-learning algorithm identified a compound that kills Acinetobacter baumannii, a bacterium that lurks in many hospital settings.
Developed at SMART, the therapy stimulates the host immune system to more effectively clear bacterial infections and accelerate infected wound healing.
Beloved professor and “titan of chemical biology” spent 15 years on the MIT faculty, leading the Department of Chemistry from 1982 to 1987.
Study finds computer models that predict molecular interactions need improvement before they can help identify drug mechanisms of action.
Using this diagnostic, doctors could avoid prescribing antibiotics in cases where they won’t be effective.
Mixing drugs into oil-based gels could offer relief for children and adults who have trouble swallowing pills.
Microbes that safely break down antibiotics could prevent opportunistic infections and reduce antibiotic resistance.
Novel lysin Abp013 has shown promising antimicrobial ability against Acinetobacter baumannii and Klebsiella pneumoniae.
SMART researchers find explanation for why some patients might experience diarrhea after taking amoxicillin-clavulanate.