Study offers an explanation for why the APOE4 gene enhances Alzheimer’s risk
The gene variant disrupts lipid metabolism, but in cell experiments the effects were reversed by choline supplements.
Down syndrome symposium highlights clinical, fundamental progress
Speakers describe studies to address Alzheimer’s disease, sleep apnea, and to advance fundamental discoveries in cell and chromosome biology.
Aspiring physician explores the many levels of human health
During her time at MIT, senior Ayesha Ng’s interests have expanded from cellular biology to the social systems that shape public health.
Silencing gene expression to cure complex diseases
Immuneering uses bioinformatics to develop new medicines while also helping large pharmaceutical companies improve their treatments.
Alzheimer’s risk gene disrupts endocytosis, but another disease-linked gene could help
Astrocytes with the APOE4 gene variant show deficits of a key cellular function, but overexpressing the gene PICALM overcame the defect.
Study finds path for addressing Alzheimer’s blood-brain barrier impairment
MIT researchers pinpoint mechanism and demonstrate that drugs could help.
Study finds that aging neurons accumulate DNA damage
Reactivating an enzyme that promotes DNA repair can help to reverse age-related cognitive decline in mice.
Studying the brain and supporting the mind
At MIT, senior Tarun Kamath has explored neuroscience and science policy, while helping his peers find ways to reduce stress.
Covid-19 calls MIT physician-scientist to front-line respiratory care
Neurologist and researcher Diane Chan pitches in to help New England get through tough times.
Two MIT professors named 2019 fellows of the National Academy of Inventors
Li-Huei Tsai and Christopher Schuh recognized for research innovations addressing Alzheimer’s disease and metal mechanics.
Alzheimer’s plaque emerges early and deep in the brain
Clumps of amyloid protein emerge early in deep regions, such as the mammillary body, and march outward in the brain along specific circuits.
Tissue model reveals role of blood-brain barrier in Alzheimer’s
Study finds that Alzheimer’s damage allows toxins to enter the brain, further harming neurons.
Characterizing tau aggregates in neurodegenerative diseases
New research reveals a structural model for amyloid fibrils that could aid in future medicinal interventions for Alzheimer's, CTE, and more.
Model predicts cognitive decline due to Alzheimer’s, up to two years out
Researchers hope the system can zero in on the right patients to enroll in clinical trials, to speed discovery of drug treatments.
From one brain scan, more information for medical artificial intelligence
System helps machine-learning models glean training information for diagnosing and treating brain conditions.