New open-source tool helps to detangle the brain
The software tool NeuroTrALE is designed to quickly and efficiently process large amounts of brain imaging data semi-automatically.
Study reveals ways in which 40Hz sensory stimulation may preserve brain’s “white matter”
Gamma frequency light and sound stimulation preserves myelination in mouse models and reveals molecular mechanisms that may underlie the benefit.
Study across multiple brain regions discerns Alzheimer’s vulnerability and resilience factors
Genomics and lab studies reveal numerous findings, including a key role for Reelin amid neuronal vulnerability, and for choline and antioxidants in sustaining cognition.
Machine learning and the microscope
PhD student Xinyi Zhang is developing computational tools for analyzing cells in the age of multimodal data.
Technologies enable 3D imaging of whole human brain hemispheres at subcellular resolution
Three innovations by an MIT-based team enable high-resolution, high-throughput imaging of human brain tissue at a full range of scales, and mapping connectivity of neurons at single-cell resolution.
Symposium highlights scale of mental health crisis and novel methods of diagnosis and treatment
Co-hosted by the McGovern Institute, MIT Open Learning, and others, the symposium stressed emerging technologies in advancing understanding of mental health and neurological conditions.
Navigating longevity with industry leaders at MIT AgeLab PLAN Forum
A symposium for financial professionals imagines a new industry around longevity planning.
Study: Movement disorder ALS and cognitive disorder FTLD show strong molecular overlaps
Single-cell gene expression patterns in the brain, and evidence from follow-up experiments, reveal many shared cellular and molecular similarities that could be targeted for potential treatment.
Envisioning a time when people age without fear of dementia
Moved by the human devastation and scientific conundrum of Alzheimer’s, William Li seeks to work on therapies for the disease.
How sensory gamma rhythm stimulation clears amyloid in Alzheimer’s mice
Study finds stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of an Alzheimer’s protein.
How cognition changes before dementia hits
Study finds language-processing difficulties are an indicator — in addition to memory loss — of amnestic mild cognitive impairment.
Evidence that gamma rhythm stimulation can treat neurological disorders is emerging
Researchers survey a broadening landscape of studies showing what’s known, and what remains to be found, about the therapeutic potential of noninvasive sensory, electrical, or magnetic stimulation of gamma brain rhythms.
Nanoparticle-delivered RNA reduces neuroinflammation in lab tests
MIT researchers find that in mice and human cell cultures, lipid nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer’s.
How a mutation in microglia elevates Alzheimer’s risk
A new study finds that microglia with mutant TREM2 protein reduce brain circuit connections, promote inflammation, and contribute to Alzheimer’s pathology in other ways.
Aging Brain Initiative symposium showcases “cutting-edge” research across MIT
Seed projects, posters represent a wide range of labs working on technologies, therapeutic strategies, and fundamental research to advance understanding of age-related neurodegenerative disease.