Koch Institute

MIT researchers have added an extra layer of control to the CRISPR gene-editing approach, by making the system responsive to light.

Using light to control genome editing

New technique offers precise manipulation of when and where genes are targeted.

August 25, 2016

In humans and most other organisms, a circadian clock governed by light regulates the timing of key aspects of human physiology, by controlling cellular activities such as metabolism and division.

Why working the night shift can pose a cancer risk

New study reveals a link between circadian clock disruption and tumor growth.

July 28, 2016

Researchers at MIT and the University of California at San Diego have delivered artificial genetic circuits into bacteria, allowing the microbes to kill cancer cells in three different ways. Here, an image of a motherboard has been micropatterned using programmable probiotic bacteria. The bright lines are composed of dots made of bacteria. This technique was developed in the lab of MIT professor S...

Cancer-fighting bacteria

Engineers program E. coli to destroy tumor cells.

July 20, 2016

Michael Mitchell has been recognized with a Burroughs Wellcome Fund Career Award at the Scientific Interface for his research on developing a new class of materials and devices that detect and treat bone marrow disorders.

Michael Mitchell wins Burroughs Wellcome Fund Career Award at the Scientific Interface

MIT postdoc is among 10 scientists honored for combining biology with the physical sciences and engineering toward medical breakthroughs.

July 5, 2016

“This nanoformulation approach allows us to make vaccines against new diseases in only seven days, allowing the potential to deal with sudden outbreaks or make rapid modifications and improvements,” says Daniel Anderson, an associate professor in MIT’s Department of Chemical Engineering and a member of MIT’s Koch Institute for Integrative Cancer Research and Institute for Medical Engineeri...

Engineers design programmable RNA vaccines

Tests in mice show the vaccines work against Ebola, influenza, and a common parasite.

July 4, 2016

A new report, “Convergence: The Future of Health,” draws on insights from scientists and researchers across academia, industry, and government. The cover of the report is an image of lungs, one of the major sites of metastasis. To help protect the lungs (blue) from this deadly process, bioengineers have created microscopic drug depots (red) to focus the effect of anti-cancer drugs that may hav...

A strategy for “convergence” research to transform biomedicine

Report calls for more integration of physical, life sciences for needed advances in biomedical research.

June 23, 2016

A Massachusetts General Hospital surgeon demonstrates the Lincoln Laboratory’s near-infrared fluorescence imaging (NIRF) system.

Glowing tumors light a path to cancer treatment

Mechanism developed at MIT and Massachusetts General Hospital shows promising results for improved ovarian cancer detection and removal.

May 20, 2016

“It’s an invisible layer that can provide a barrier, provide cosmetic improvement, and potentially deliver a drug locally to the area that’s being treated. Those three things together could really make it ideal for use in humans,” Daniel Anderson says.

New material temporarily tightens skin

“Second skin” polymer could also be used to protect dry skin and deliver drugs.

May 9, 2016

(Top) Stimulating the growth of new blood vessels (angiogenesis) in adipose tissue transforms the tissue from fat-storing white tissue to fat-burning brown tissue. A schematic of the nanoparticle (bottom left) that MIT and Brigham and Women’s Hospital researchers used to deliver angiogenesis drugs to adipose tissue. (Bottom right) The nanoparticles imaged by transmission electron microscopy.

Fat-fighting nanoparticles

New drug-delivery approach holds potential for treating obesity.

May 2, 2016

Winning team IllumiRNA (shown here) pitched an idea for a diagnostic platform that profiles individual cells in blood tests.

Method for earlier detection of leukemia wins $300,000 grant

Team takes home grand prize from Koch Institute’s unique research-grant pitch competition.

April 11, 2016

Researchers have created a new type of dual-sided pill that attaches to the gastrointestinal tract. One side of the pill sticks to mucosal surfaces, while the other is omniphobic, meaning that it repels everything it encounters.

Engineers develop a pill for long-term drug release

New tablet attaches to the lining of the GI tract, resists being pulled away.

April 6, 2016

School of Science honors staff with 2016 Infinite Mile Awards

March 28, 2016

Science art on display at the public galleries of MIT's Koch Institute for Integrative Cancer Research

Scientific art lights up Main Street

Art and science converge in the public galleries at MIT's Koch Institute for Integrative Cancer Research.

March 23, 2016

(Left to right) Miles Miller, Frank Gertler, Douglas Lauffenburger, and Madeleine Oudin in the Gertler Lab at MIT.

Why some tumors withstand treatment

Researchers uncover a mechanism that allows cancer cells to evade targeted therapies.

March 16, 2016

This image depicts the process of metastasis in a mouse tumor, where tumor cells (green) have helped to reorganize the collagen into aligned fibers (blue) that provide the structural support for motility. This helps the tumor cells to enter blood vessels (red), ultimately leading to the formation of metastases in other organs.

Paving the way for metastasis

Cancer cells remodel their environment to make it easier to reach nearby blood vessels.

March 15, 2016

MIT News | Massachusetts Institute of Technology

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